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Rab5al1 Rab5a, member RAS oncogene family-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361891, updated on 11-Jun-2025
Symbol
Rab5al1provided by RGD
Full Name
Rab5a, member RAS oncogene family-like 1provided by RGD
Primary source
RGD:2319287
See related
Ensembl:ENSRNOG00000062595 AllianceGenome:RGD:2319287
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein activity and GTP binding activity. Involved in endosome organization; postsynaptic neurotransmitter receptor internalization; and synaptic vesicle endocytosis. Located in several cellular components, including axon terminus; cytoplasmic vesicle; and neuronal cell body. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynaptic endocytic zone membrane. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jun 2025]
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See Rab5al1 in Genome Data Viewer
Location:
14q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (72544798..72546910)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (68332360..68334470)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (72889022..72891156)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481851 Neighboring gene uncharacterized LOC103693082 Neighboring gene ribosomal protein S11, pseudogene 1 Neighboring gene uncharacterized LOC134481762

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Endosomal sorting of readily releasable synaptic vesicles. Hoopmann P, et al. Proc Natl Acad Sci U S A, 2010 Nov 2. PMID 20956291, Free PMC Article
  2. EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. Wilson JM, et al. Mol Biol Cell, 2000 Aug. PMID 10930461, Free PMC Article
  3. NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. Brown TC, et al. Neuron, 2005 Jan 6. PMID 15629704
  4. The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. de Hoop MJ, et al. Neuron, 1994 Jul. PMID 8043272
  5. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, et al. Elife, 2019 May 10. PMID 31074746, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in plasma membrane to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynaptic endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in somatodendritic compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in terminal bouton HDA PubMed 
located_in terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
ras-related protein Rab-5A

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    72544798..72546910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003751377.6 → XP_003751425.1  ras-related protein Rab-5A

    See identical proteins and their annotated locations for XP_003751425.1

    UniProtKB/Swiss-Prot
    M0RC99, O88565
    UniProtKB/TrEMBL
    A0A8I6A5S3
    Related
    ENSRNOP00000096260.1, ENSRNOT00000100183.2
    Conserved Domains (1) summary
    cd01860
    Location:20 → 182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
Nucleotide Protein Strain
Heading Accession and Version

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