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CHAF1A chromatin assembly factor 1 subunit A [ Homo sapiens (human) ]

Gene ID: 10036, updated on 5-Sep-2021

Summary

Official Symbol
CHAF1Aprovided by HGNC
Official Full Name
chromatin assembly factor 1 subunit Aprovided by HGNC
Primary source
HGNC:HGNC:1910
See related
Ensembl:ENSG00000167670 MIM:601246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAF1; P150; CAF-1; CAF1B; CAF1P150
Summary
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in bone marrow (RPKM 7.4), testis (RPKM 6.1) and 24 other tissues See more
Orthologs
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Genomic context

See CHAF1A in Genome Data Viewer
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4402596..4448322)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4402637..4443394)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 262 and 14493 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene Sharpr-MPRA regulatory regions 465 and 6457 Neighboring gene uncharacterized LOC107985297 Neighboring gene microRNA 4746 Neighboring gene UBX domain protein 6 Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromatin assembly factor 1, subunit A (CHAF1A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with chromatin assembly factor 1, subunit A (CHAF1A; CAF1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with chromatin assembly factor 1, subunit A (CHAF1A; CAF1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71229

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding TAS
Traceable Author Statement
more info
PubMed 
enables chromo shadow domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chromatin assembly factor 1 subunit A
Names
CAF-1 subunit A
CAF-I 150 kDa subunit
CAF-I p150
CTB-50L17.7
chromatin assembly factor I (150 kDa)
chromatin assembly factor I p150 subunit
hp150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005483.3NP_005474.2  chromatin assembly factor 1 subunit A

    See identical proteins and their annotated locations for NP_005474.2

    Status: VALIDATED

    Source sequence(s)
    AA576757, AC011498, BC052620, BE796132, BG775588, BM826511, BQ889365, H98924, U20979
    Consensus CDS
    CCDS32875.1
    UniProtKB/Swiss-Prot
    Q13111
    Related
    ENSP00000301280.4, ENST00000301280.10
    Conserved Domains (4) summary
    pfam11600
    Location:320479
    CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
    pfam12253
    Location:558601
    CAF1A; Chromatin assembly factor 1 subunit A
    pfam15539
    Location:665954
    CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
    pfam15557
    Location:1226
    CAF1-p150_N; CAF1 complex subunit p150, region binding to PCNA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4402596..4448322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527605.2XP_011525907.1  chromatin assembly factor 1 subunit A isoform X1

    Conserved Domains (4) summary
    pfam11600
    Location:320479
    CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
    pfam12253
    Location:558601
    CAF1A; Chromatin assembly factor 1 subunit A
    pfam15539
    Location:665943
    CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
    pfam15557
    Location:1226
    CAF1-p150_N; CAF1 complex subunit p150, region binding to PCNA
  2. XM_011527606.2XP_011525908.1  chromatin assembly factor 1 subunit A isoform X2

    Conserved Domains (4) summary
    pfam11600
    Location:320479
    CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
    pfam12253
    Location:558601
    CAF1A; Chromatin assembly factor 1 subunit A
    pfam15539
    Location:665923
    CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
    pfam15557
    Location:1226
    CAF1-p150_N; CAF1 complex subunit p150, region binding to PCNA
  3. XM_011527607.2XP_011525909.1  chromatin assembly factor 1 subunit A isoform X3

    Conserved Domains (4) summary
    pfam11600
    Location:382460
    CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
    pfam12253
    Location:539582
    CAF1A; Chromatin assembly factor 1 subunit A
    pfam15539
    Location:646935
    CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
    pfam15557
    Location:1226
    CAF1-p150_N; CAF1 complex subunit p150, region binding to PCNA

RNA

  1. XR_936135.2 RNA Sequence

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