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PARK16 Parkinson disease 16 (susceptibility) [ Homo sapiens (human) ]

Gene ID: 100359403, updated on 23-Jan-2022

Summary

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Gene symbol
PARK16
Gene description
Parkinson disease 16 (susceptibility)
Primary source
MIM:613164
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Genomic context

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Location:
1q32

Bibliography

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Related articles in PubMed

  1. The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease. Gu LY, et al. Brain Struct Funct, 2021 Nov. PMID 34373950
  2. Association between rs823128 polymorphism and the risk of Parkinson's disease: A meta-analysis. Cai M, et al. Neurosci Lett, 2018 Feb 5. PMID 29191693
  3. PARK16 is associated with PD in the Malaysian population. Gopalai AA, et al. Am J Med Genet B Neuropsychiatr Genet, 2016 Sep. PMID 27174169
  4. PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan. Miyake Y, et al. J Neurol Sci, 2016 Mar 15. PMID 26944116
  5. Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population. Xia H, et al. Genet Mol Res, 2015 Apr 10. PMID 25966061

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease.
    Title: The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease.
  2. Within its limitations, this meta-analysis demonstrated that the rs823128 variants(G allele, GA and GG genotype)in PARK16 might be a potential protective factor for Parkinson's disease[meta-analysis]
    Title: Association between rs823128 polymorphism and the risk of Parkinson's disease: A meta-analysis.
  3. PARK16 locus rs947211 polymorphism (A allele, AG and GG genotype) may be a protective factor for PD in overall populations, particularly in Northeast Asian populations.
    Title: Association between PARK16 and Parkinson's disease: A meta-analysis.
  4. Interaction between LRRK2 and PARK16 loci variants do not influence risk of Parkinson's disease.
    Title: Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
  5. 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing Parkinson's disease (PD) via a recessive model. A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model. Three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model.
    Title: PARK16 is associated with PD in the Malaysian population.
  6. The PARK16 SNPs rs823128, rs947211, and rs823156 and the CAAAC, TGAGA, and CAGAC haplotypes may be significantly associated with sporadic PD in Japan
    Title: PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan.
  7. Different PARK16 linkage disequilibrium patterns across Chinese, Japanese, Indian, Malay, and Caucasian groups.
    Title: Patterns of linkage disequilibrium at PARK16 may explain variances in genetic association studies.
  8. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD
    Title: Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population.
  9. Allelic heterogeneity at PARK16 appears a likely contributing factor in Parkinson disease.
    Title: Fine mapping and resequencing of the PARK16 locus in Parkinson's disease.
  10. study investigated association of 5 SNPs (rs823083, rs708723, rs4951261, rs823076 and rs16856110) at the PARK16 locus with Parkinson's disease (PD); the 4 SNPs, rs16856110, rs4951261, rs708723 and rs823076, which were in linkage equilibrium, should not be associated with PD
    Title: Association of five SNPs at the PARK16 locus as a susceptibility locus with Parkinson's disease for forensic application.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Parkinson disease 16 (susceptibility)

General gene information

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Property

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