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NOD2 nucleotide binding oligomerization domain containing 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100356594, updated on 17-Dec-2024
Gene symbol
NOD2
Gene description
nucleotide binding oligomerization domain containing 2
See related
Ensembl:ENSOCUG00000012840
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
all
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Try the new Transcripts and proteins table
See NOD2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 18 NC_091449.1 (34241672..34282761)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 5 NC_067378.1 (7173916..7215042)

Chromosome 18 - NC_091449.1Genomic Context describing neighboring genes Neighboring gene NKD inhibitor of WNT signaling pathway 1 Neighboring gene sorting nexin 20 Neighboring gene CYLD lysine 63 deubiquitinase Neighboring gene U6 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection. Guo M, et al. Front Cell Infect Microbiol, 2018. PMID 29998088, Free PMC Article
  2. A synonymous mutation in NOD2 gene was significantly associated with non-specific digestive disorder in rabbit. Zhang WX, et al. Gene, 2013 Mar 10. PMID 23296055
  3. Crystal structure of NOD2 and its implications in human disease. Maekawa S, et al. Nat Commun, 2016 Jun 10. PMID 27283905, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that NOD2 can significantly activate NF-kappaB signaling and trigger antibacterial defenses to increase the expression of pro-inflammatory cytokine and defensins after stimulation by enterohemorrhagic Escherichia coli.
    Title: Protective Role of Rabbit Nucleotide-Binding Oligomerization Domain-2 (NOD2)-Mediated Signaling Pathway in Resistance to Enterohemorrhagic Escherichia coli Infection.
  2. the crystal structure of rabbit NOD2 in an ADP-bound state, is reported.
    Title: Crystal structure of NOD2 and its implications in human disease.
  3. A synonymous mutation in NOD2 gene was significantly associated with non-specific digestive disorder in rabbit.
    Title: A synonymous mutation in NOD2 gene was significantly associated with non-specific digestive disorder in rabbit.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
nucleotide-binding oligomerization domain-containing protein 2
Names
nucleotide oligomerization domain 2 protein

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RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091449.1 Reference mOryCun1.1

    Range
    34241672..34282761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008275042.4 → XP_008273264.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_008273264.1

    UniProtKB/Swiss-Prot
    A0A2S0UTH0, G1T469
    UniProtKB/TrEMBL
    A0A5F9DQU6
    Related
    ENSOCUP00000011052.3
    Conserved Domains (5) summary
    cd08788
    Location:107 → 186
    CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2
    sd00033
    Location:793 → 817
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266 → 436
    NACHT; NACHT domain
    cl14633
    Location:7 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl26161
    Location:793 → 983
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_008275044.4 → XP_008273266.2  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A5F9DQU6

  3. XM_017350884.3 → XP_017206373.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A5F9CH96, A0A5F9DQU6
    Related
    ENSOCUP00000032966.1

  4. XM_070063177.1 → XP_069919278.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

RNA

  1. XR_001795775.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G1T469.2 GenPept UniProtKB/Swiss-Prot:G1T469

Gene LinkOut

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Molecular Biology Databases
Research Materials