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CBLB Cbl proto-oncogene B [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100355469, updated on 17-Dec-2024
Gene symbol
CBLB
Gene description
Cbl proto-oncogene B
See related
Ensembl:ENSOCUG00000005590
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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See CBLB in Genome Data Viewer
Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 4 NC_091435.1 (60700679..60935313, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 14 NC_067387.1 (115344078..115578334)

Chromosome 4 - NC_091435.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene synaptophysin-like protein 1 pseudogene Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC127482951 Neighboring gene U2 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091435.1 Reference mOryCun1.1

    Range
    60700679..60935313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_070072032.1 → XP_069928133.1  E3 ubiquitin-protein ligase CBL-B isoform X9

  2. XM_008267006.4 → XP_008265228.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_008265228.1

    UniProtKB/TrEMBL
    A0A5F9CNV5, G1SP98
    Related
    ENSOCUP00000004853.2
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373 → 415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_070072028.1 → XP_069928129.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    UniProtKB/TrEMBL
    A0A5F9CNV5

  4. XM_070072027.1 → XP_069928128.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    UniProtKB/TrEMBL
    A0A5F9CNV5

  5. XM_070072026.1 → XP_069928127.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A5F9CNV5

  6. XM_051819103.2 → XP_051675063.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    UniProtKB/TrEMBL
    A0A5F9CNV5

  7. XM_051819102.2 → XP_051675062.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    UniProtKB/TrEMBL
    A0A5F9CNV5

  8. XM_051819101.2 → XP_051675061.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A5F9CNV5

  9. XM_051819100.2 → XP_051675060.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A5F9CNV5, G1SP98

  10. XM_070072029.1 → XP_069928130.1  E3 ubiquitin-protein ligase CBL-B isoform X5

  11. XM_070072025.1 → XP_069928126.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A5F9CNV5

  12. XM_002716724.5 → XP_002716770.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_002716770.1

    UniProtKB/TrEMBL
    A0A5F9CNV5, G1SP98
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373 → 415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  13. XM_070072030.1 → XP_069928131.1  E3 ubiquitin-protein ligase CBL-B isoform X7

    UniProtKB/TrEMBL
    A0A5F9CNV5

  14. XM_051819106.2 → XP_051675066.1  E3 ubiquitin-protein ligase CBL-B isoform X7

    UniProtKB/TrEMBL
    A0A5F9CNV5

  15. XM_051819105.2 → XP_051675065.1  E3 ubiquitin-protein ligase CBL-B isoform X6

    UniProtKB/TrEMBL
    A0A5F9CNV5

  16. XM_051819107.2 → XP_051675067.1  E3 ubiquitin-protein ligase CBL-B isoform X8

Nucleotide Protein
Heading Accession and Version

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