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TDP1 tyrosyl-DNA phosphodiesterase 1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100349532, updated on 2-Dec-2024

Summary

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Gene symbol
TDP1
Gene description
tyrosyl-DNA phosphodiesterase 1
See related
Ensembl:ENSOCUG00000002106
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See TDP1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 20 NC_091451.1 (35624383..35712484)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 20 NC_067393.1 (15132274..15219576, complement)

Chromosome 20 - NC_091451.1Genomic Context describing neighboring genes Neighboring gene forkhead box N3 Neighboring gene uncharacterized LOC138847277 Neighboring gene EF-hand calcium binding domain 11 Neighboring gene binder of sperm 1 Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene proteasome 26S subunit, ATPase 1 Neighboring gene NRDE-2, necessary for RNA interference, domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-tyrosyl-DNA phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosyl-DNA phosphodiesterase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091451.1 Reference mOryCun1.1

    Range
    35624383..35712484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008271930.3 → XP_008270152.1  tyrosyl-DNA phosphodiesterase 1

    UniProtKB/TrEMBL
    A0A5F9C249, G1SGT8
    Conserved Domains (3) summary
    cd09193
    Location:163 → 331
    PLDc_mTdp1_1; Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
    cd09195
    Location:353 → 546
    PLDc_mTdp1_2; Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
    pfam06087
    Location:166 → 583
    Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase

  2. XM_008271933.3 → XP_008270155.1  tyrosyl-DNA phosphodiesterase 1

    UniProtKB/TrEMBL
    A0A5F9C249, G1SGT8
    Conserved Domains (3) summary
    cd09193
    Location:163 → 331
    PLDc_mTdp1_1; Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
    cd09195
    Location:353 → 546
    PLDc_mTdp1_2; Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
    pfam06087
    Location:166 → 583
    Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase

  3. XM_002719604.5 → XP_002719650.1  tyrosyl-DNA phosphodiesterase 1

    UniProtKB/TrEMBL
    A0A5F9C249, G1SGT8
    Related
    ENSOCUP00000001816.3
    Conserved Domains (3) summary
    cd09193
    Location:163 → 331
    PLDc_mTdp1_1; Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
    cd09195
    Location:353 → 546
    PLDc_mTdp1_2; Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
    pfam06087
    Location:166 → 583
    Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase

  4. XM_070065523.1 → XP_069921624.1  tyrosyl-DNA phosphodiesterase 1

Nucleotide Protein
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