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TNKS2 tankyrase 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100340857, updated on 17-Dec-2024

Summary

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Gene symbol
TNKS2
Gene description
tankyrase 2
See related
Ensembl:ENSOCUG00000012010
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See TNKS2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 15 NC_091446.1 (38636064..38701536, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 18 NC_067391.1 (36629347..36694671)

Chromosome 15 - NC_091446.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene UBX domain-containing protein 8 pseudogene Neighboring gene uncharacterized LOC127484150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to ciliary inversin compartment IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary inversin compartment IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091446.1 Reference mOryCun1.1

    Range
    38636064..38701536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_070057626.1 → XP_069913727.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

    UniProtKB/TrEMBL
    A0A5F9D783

  2. XM_008270191.4 → XP_008268413.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    UniProtKB/TrEMBL
    A0A5F9D783
    Related
    ENSOCUP00000042049.1
    Conserved Domains (9) summary
    cd09524
    Location:808 → 873
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:814 → 870
    SAM; Sterile alpha motif
    cd00204
    Location:518 → 643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:875 → 1097
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00023
    Location:681 → 710
    Ank; Ankyrin repeat
    pfam00644
    Location:889 → 1092
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:530 → 622
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 78
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]

  3. XM_008270190.4 → XP_008268412.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    UniProtKB/TrEMBL
    G1T2F9
    Conserved Domains (8) summary
    cd09524
    Location:871 → 936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:877 → 933
    SAM; Sterile alpha motif
    cd00204
    Location:518 → 643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:941 → 1149
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:941 → 1144
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:530 → 622
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 78
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]

  4. XM_002718506.5 → XP_002718552.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    UniProtKB/TrEMBL
    G1T2F9
    Related
    ENSOCUP00000010336.3
    Conserved Domains (8) summary
    cd09524
    Location:871 → 936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:877 → 933
    SAM; Sterile alpha motif
    cd00204
    Location:518 → 643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:938 → 1160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:952 → 1155
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:530 → 622
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 78
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]
Nucleotide Protein
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