cd209 CD209 molecule [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cd209provided by ZNC
Official Full Name: CD209 moleculeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061207-22
See related: Ensembl:ENSDARG00000029461 AllianceGenome:ZFIN:ZDB-GENE-061207-22
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DC-SIGN; si:ch211-214k5.1; si:ch211-224h1.3
Summary: Predicted to enable carbohydrate binding activity. Acts upstream of or within T cell activation involved in immune response; adaptive immune response; and dendritic cell antigen processing and presentation. Located in cell surface. Is expressed in several structures, including heart; immune system; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CLEC6A (C-type lectin domain containing 6A); CLEC4A (C-type lectin domain family 4 member A); and CLEC4C (C-type lectin domain family 4 member C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (24971429..25028518, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (25001977..25059066, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identification and functional characterization of DC-SIGN/CD209 molecule in zebrafish
Title: The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fucose binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendritic cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD209 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199373.2 → NP_001186302.2 CD209 antigen

Status: VALIDATED

Source sequence(s)

BX897671

UniProtKB/TrEMBL

A0A8M1NXD2, F1QW96

Related

ENSDARP00000040732.3, ENSDART00000040733.5

Conserved Domains (2) summary

cd03590
Location:220 → 337

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl11433
Location:94 → 183

DivIC; Septum formation initiator