bcl10 BCL10 immune signaling adaptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bcl10provided by ZNC
Official Full Name: BCL10 immune signaling adaptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-100219-2
See related: Ensembl:ENSDARG00000077130 AllianceGenome:ZFIN:ZDB-GENE-100219-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable NF-kappaB binding activity; protein kinase B binding activity; and transcription coactivator activity. Predicted to contribute to kinase activator activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity. Located in cytoplasm. Part of CBM complex. Is expressed in gill; intestine; male organism; and spleen. Human ortholog(s) of this gene implicated in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	2	NC_133177.1 (2092765..2101774)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (1945328..1954216)

Chromosome 2 - NC_133177.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

characterization of zebrafish (Danio rerio) Bcl10
Title: Functional characterization of zebrafish (Danio rerio) Bcl10.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase B binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CBM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CBM complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain