vipr1a vasoactive intestinal peptide receptor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vipr1aprovided by ZNC
Official Full Name: vasoactive intestinal peptide receptor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-506
See related: Ensembl:ENSDARG00000028878 AllianceGenome:ZFIN:ZDB-GENE-070912-506
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-29d8.1
Summary: Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and vasoactive intestinal polypeptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in achalasia. Orthologous to human VIPR1 (vasoactive intestinal peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	2	NC_133177.1 (24452972..24522613)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21229925..21301199)

Chromosome 2 - NC_133177.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables vasoactive intestinal polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_002660797.6 → XP_002660843.2 vasoactive intestinal polypeptide receptor isoform X1

UniProtKB/TrEMBL

A0A8M1RDB6, F1R788

Related

ENSDARP00000046126.6

Conserved Domains (2) summary

pfam00002
Location:122 → 367

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:46 → 96

HRM; Hormone receptor domain
XM_073924977.1 → XP_073781078.1 vasoactive intestinal polypeptide receptor isoform X3
XM_073924972.1 → XP_073781073.1 vasoactive intestinal polypeptide receptor isoform X2