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gucy2g guanylate cyclase 2g [ Danio rerio (zebrafish) ]

Gene ID: 100333350, updated on 2-Nov-2024

Summary

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Official Symbol
gucy2gprovided by ZNC
Official Full Name
guanylate cyclase 2gprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130531-70
See related
Ensembl:ENSDARG00000076776 AllianceGenome:ZFIN:ZDB-GENE-130531-70
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-92e20.2
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within cyclic nucleotide biosynthetic process; intracellular signal transduction; and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See gucy2g in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (31460851..31476498)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (31345768..31361480)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene acyl-CoA synthetase long chain family member 5 Neighboring gene tectorin beta Neighboring gene FERM domain-containing protein 6 Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Saraiva LR, et al. Sci Rep, 2015 Jun 25. PMID 26108469, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate cyclase 2G
Names
zmp:0000000809

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    31460851..31476498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306792.4 → XP_009305067.2  guanylate cyclase 2G isoform X1

    UniProtKB/TrEMBL
    A0A8M3B4S0, E7FDF3
    Related
    ENSDARP00000033462.6, ENSDART00000031154.7

  2. XM_002663981.7 → XP_002664027.2  guanylate cyclase 2G isoform X2

    UniProtKB/TrEMBL
    A0A8M1RKJ8
    Conserved Domains (7) summary
    smart00044
    Location:845 → 1036
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1057
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:54 → 405
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:820 → 865
    HNOBA; Heme NO binding associated
    pfam07714
    Location:546 → 805
    Pkinase_Tyr; Protein tyrosine kinase
    cl10011
    Location:37 → 425
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21453
    Location:530 → 806
    PKc_like; Protein Kinases, catalytic domain

  3. XM_009306793.4 → XP_009305068.1  guanylate cyclase 2G isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYJ9
    Conserved Domains (7) summary
    smart00044
    Location:748 → 939
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:774 → 960
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:21 → 308
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:723 → 768
    HNOBA; Heme NO binding associated
    pfam07714
    Location:449 → 708
    Pkinase_Tyr; Protein tyrosine kinase
    cl10011
    Location:16 → 328
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21453
    Location:433 → 709
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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