mhc2d8.37b2 major histocompatibility complex class II d8.37b2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc2d8.37b2provided by ZNC
Official Full Name: major histocompatibility complex class II d8.37b2provided by ZNC
Primary source: ZFIN:ZDB-GENE-091204-413
See related: Ensembl:ENSDARG00000076307 AllianceGenome:ZFIN:ZDB-GENE-091204-413
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:zfos-2070c2.3
Summary: Predicted to enable MHC class II protein complex binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of MHC class II protein complex. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2); and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (36398615..36412858, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (36366181..36380417, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rano class II histocompatibility antigen, A beta chain-like

Names: mhc2d8.37b2p

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

36398615..36412858 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009304138.3 → XP_009302413.1 rano class II histocompatibility antigen, A beta chain-like

UniProtKB/TrEMBL

A0A0R4ISW2, A0A8M3AVD5

Related

ENSDARP00000140023.1, ENSDART00000159276.2

Conserved Domains (2) summary

smart00921
Location:33 → 100

MHC_II_beta; Class II histocompatibility antigen, beta domain

pfam07654
Location:123 → 203

C1-set; Immunoglobulin C1-set domain