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ttbk1a tau tubulin kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 100332125, updated on 27-Mar-2024

Summary

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Official Symbol
ttbk1aprovided by ZNC
Official Full Name
tau tubulin kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100609-4
See related
Ensembl:ENSDARG00000056019 AllianceGenome:ZFIN:ZDB-GENE-100609-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Orthologous to human TTBK1 (tau tubulin kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (30663307..30727951)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (30416105..30480767)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene two pore segment channel 3 Neighboring gene uncharacterized LOC110440103 Neighboring gene solute carrier family 22 member 7a Neighboring gene WD repeat domain 83 opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e. Dragojević J, et al. Toxicol In Vitro, 2018 Feb. PMID 29030288
  2. Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). Mihaljevic I, et al. BMC Genomics, 2016 Aug 12. PMID 27519738, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tau-tubulin kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    30663307..30727951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306131.3 → XP_009304406.1  tau-tubulin kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_009304406.1

    UniProtKB/TrEMBL
    A0A8M3AXQ7
    Related
    ENSDARP00000134459.1, ENSDART00000161662.2
    Conserved Domains (2) summary
    pfam00069
    Location:21 → 269
    Pkinase; Protein kinase domain
    cl21453
    Location:20 → 284
    PKc_like; Protein Kinases, catalytic domain

  2. XM_009306132.3 → XP_009304407.1  tau-tubulin kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_009304407.1

    UniProtKB/TrEMBL
    A0A8M3AXQ7
    Conserved Domains (2) summary
    pfam00069
    Location:21 → 269
    Pkinase; Protein kinase domain
    cl21453
    Location:20 → 284
    PKc_like; Protein Kinases, catalytic domain

  3. XM_009306130.3 → XP_009304405.1  tau-tubulin kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BDS7
    Related
    ENSDARP00000008788.8, ENSDART00000023981.9
    Conserved Domains (2) summary
    pfam00069
    Location:50 → 295
    Pkinase; Protein kinase domain
    cl21453
    Location:49 → 310
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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