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cdkn2a/b cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) [ Danio rerio (zebrafish) ]

Gene ID: 100329528, updated on 9-Sep-2025
Official Symbol
cdkn2a/bprovided by ZNC
Official Full Name
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)provided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-306
See related
Ensembl:ENSDARG00000037262 AllianceGenome:ZFIN:ZDB-GENE-081104-306
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p16; si:dkey-123o10.1
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in digestive system; eye; heart; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See cdkn2a/b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 1 NC_133176.1 (27775355..27778914, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26128928..26131201, complement)

Chromosome 1 - NC_133176.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490010 Neighboring gene topoisomerase I binding, arginine/serine-rich a Neighboring gene NADH:ubiquinone oxidoreductase subunit B Neighboring gene methylthioadenosine phosphorylase Neighboring gene CXXC finger 4 Neighboring gene uncharacterized LOC141385664 Neighboring gene zgc:123060

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Zapilko V, et al. Cancers (Basel), 2023 Dec 13. PMID 38136366, Free PMC Article
  2. Developmentally-programmed cellular senescence is conserved and widespread in zebrafish. Da Silva-Álvarez S, et al. Aging (Albany NY), 2020 Sep 29. PMID 32991320, Free PMC Article
  3. Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. Shim J, et al. Oncotarget, 2017 Aug 15. PMID 28903419, Free PMC Article
  4. Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish. Lex K, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32554492, Free PMC Article
  5. Targeting senescent cells improves functional recovery after spinal cord injury. Paramos-de-Carvalho D, et al. Cell Rep, 2021 Jul 6. PMID 34233184

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart.
    Title: Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
cyclin-dependent kinase inhibitor 2A
Names
cdkn2b
ink4b

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133176.1 Reference GRCz12tu Primary Assembly

    Range
    27775355..27778914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002660468.7 → XP_002660514.1  cyclin-dependent kinase inhibitor 2A

    UniProtKB/TrEMBL
    A0A8M1RH19, E9QFU2
    Related
    ENSDARP00000054208.6
    Conserved Domains (3) summary
    cd00204
    Location:8 → 122
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:8 → 100
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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