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ACE2 angiotensin converting enzyme 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100327258, updated on 20-Feb-2025
Gene symbol
ACE2
Gene description
angiotensin converting enzyme 2
See related
Ensembl:ENSOCUG00000017782
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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See ACE2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) X NC_091453.1 (1682949..1729738, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) X NC_067395.1 (1394789..1442148, complement)

Chromosome X - NC_091453.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC138847718 Neighboring gene vascular endothelial growth factor D Neighboring gene pirin Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene U2 spliceosomal RNA Neighboring gene ADP-ribosylation factor 1 pseudogene Neighboring gene collectrin, amino acid transport regulator

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure. Kar S, et al. J Appl Physiol (1985), 2010 Apr. PMID 20093667, Free PMC Article
  2. [Overexpression of angiotensin converting enzyme 2 inhibits inflammatory response of atherosclerotic plaques in hypercholesterolemic rabbits]. Dong B, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2009 Jul. PMID 19961735
  3. Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2. Zhao X, et al. J Virol, 2020 Aug 31. PMID 32661139, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activation of the central rennin-angiotensin system in animals with chronic heart failure involves an imbalance of ACE and ACE2 in regions of the brain that regulate autonomic function.
    Title: Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure.
  2. Overexpression of ACE2 inhibited atherosclerotic plaque inflammation response in hypercholesterolemic rabbits.
    Title: [Overexpression of angiotensin converting enzyme 2 inhibits inflammatory response of atherosclerotic plaques in hypercholesterolemic rabbits].
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
angiotensin-converting enzyme 2
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
angiotensin I converting enzyme 2

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RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091453.1 Reference mOryCun1.1

    Range
    1682949..1729738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051826945.2 → XP_051682905.2  angiotensin-converting enzyme 2

    UniProtKB/TrEMBL
    G1TEF4

  2. XM_002719845.5 → XP_002719891.2  angiotensin-converting enzyme 2

    UniProtKB/TrEMBL
    G1TEF4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials