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MIR146A microRNA mir-146a [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100314742, updated on 30-Apr-2024
Gene symbol
MIR146A
Gene description
microRNA mir-146a
See related
Ensembl:ENSOANG00000017048 miRBase:MI0006931
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Also known as
oan-mir-146a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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See MIR146A in Genome Data Viewer
Location:
chromosome: X1
Exon count:
1
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) X1 NC_041749.1 (27130003..27130131, complement)

Chromosome X1 - NC_041749.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103164699 Neighboring gene small nucleolar RNA SNORA7 Neighboring gene ATPase phospholipid transporting 10B (putative) Neighboring gene uncharacterized LOC120638016 Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene spliceosome associated SLU7

Genomic Sequence:
NC_041749.1 Chromosome X1 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Conservation of small RNA pathways in platypus. Murchison EP, et al. Genome Res, 2008 Jun. PMID 18463306, Free PMC Article
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Other Names

  • microRNA 146a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_034887.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    RZJT01000022
    Related
    ENSOANT00000026191.2

RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041749.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    27130003..27130131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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