U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mir20a microRNA 20a [ Rattus norvegicus (Norway rat) ]

Gene ID: 100314222, updated on 10-Jul-2024

Summary

Official Symbol
Mir20aprovided by RGD
Official Full Name
microRNA 20aprovided by RGD
Primary source
RGD:2325401
See related
EnsemblRapid:ENSRNOG00000035605 miRBase:MI0000638; AllianceGenome:RGD:2325401
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rno-mir-20a
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mir20a in Genome Data Viewer
Location:
15q23
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (98588303..98588387)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (92181084..92181168)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (100180334..100180418)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene microRNA 18a Neighboring gene microRNA 19a Neighboring gene microRNA 19b-1 Neighboring gene microRNA 92a-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Other Names

  • microRNA mir-20a

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA base-pairing translational repressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid precursor protein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pre-B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_031793.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    Related
    ENSRNOT00000053728.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    98588303..98588387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)