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Mir182 microRNA 182 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100314172, updated on 5-Jul-2025
Symbol
Mir182provided by RGD
Full Name
microRNA 182provided by RGD
Primary source
RGD:4888616
See related
miRBase:MI0006133; AllianceGenome:RGD:4888616
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rno-mir-182
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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See Mir182 in Genome Data Viewer
Location:
4q22
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59752246..59752307, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58784818..58784879, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57459773..57459834, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102484 Neighboring gene nuclear respiratory factor 1 Neighboring gene microRNA 3553 Neighboring gene microRNA 183 Neighboring gene microRNA 96

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Inhibition of miR-182-5p attenuates ROS and protects against myocardial ischemia-reperfusion injury by targeting STK17A. Li X, et al. Cell Cycle, 2022 Aug. PMID 35503215, Free PMC Article
  2. MicroRNA-182 regulates amygdala-dependent memory formation. Griggs EM, et al. J Neurosci, 2013 Jan 23. PMID 23345246, Free PMC Article
  3. LncRNA PCAT19 Regulates Neuropathic Pain via Regulation of miR-182-5p/JMJD1A in a Rat Model of Chronic Constriction Injury. Huo M, et al. Neuroimmunomodulation, 2022. PMID 34518490
  4. MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3. Du Y, et al. Urol Int, 2021. PMID 33965964
  5. MicroRNA-182 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Smad1. Zheng HB, et al. J Biol Regul Homeost Agents, 2021 Mar-Apr. PMID 33691396

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-182 promotes apoptosis of neural cells in cerebral infarction rats by PI3K/AKT signaling pathway.
    Title: MiR-182 promotes apoptosis of neural cells in cerebral infarction rats by PI3K/AKT signaling pathway.
  2. Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus.
    Title: Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus.
  3. Inhibition of miR-182-5p attenuates ROS and protects against myocardial ischemia-reperfusion injury by targeting STK17A.
    Title: Inhibition of miR-182-5p attenuates ROS and protects against myocardial ischemia-reperfusion injury by targeting STK17A.
  4. LncRNA PCAT19 Regulates Neuropathic Pain via Regulation of miR-182-5p/JMJD1A in a Rat Model of Chronic Constriction Injury.
    Title: LncRNA PCAT19 Regulates Neuropathic Pain via Regulation of miR-182-5p/JMJD1A in a Rat Model of Chronic Constriction Injury.
  5. MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.
    Title: MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.
  6. HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
    Title: HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
  7. LncRNA CHRF aggravates myocardial ischemia/reperfusion injury by enhancing autophagy via modulation of the miR-182-5p/ATG7 pathway.
    Title: LncRNA CHRF aggravates myocardial ischemia/reperfusion injury by enhancing autophagy via modulation of the miR-182-5p/ATG7 pathway.
  8. MiR-182 inhibits oxidative stress and epithelial cell apoptosis in lens of cataract rats through PI3K/Akt signaling pathway.
    Title: MiR-182 inhibits oxidative stress and epithelial cell apoptosis in lens of cataract rats through PI3K/Akt signaling pathway.
  9. MicroRNA-182 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Smad1.
    Title: MicroRNA-182 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targeting Smad1.
  10. miR-182 prevented ototoxic deafness induced by co-administration of kanamycin and furosemide in rats.
    Title: miR-182 prevented ototoxic deafness induced by co-administration of kanamycin and furosemide in rats.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Other Names

  • microRNA mir-182

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA base-pairing post-transcriptional repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female sex differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Schwann cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Schwann cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal cone cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_037314.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59752246..59752307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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