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Mir322 microRNA 322 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100314144, updated on 5-Jul-2025
Symbol
Mir322provided by RGD
Full Name
microRNA 322provided by RGD
Primary source
RGD:2325467
See related
miRBase:MI0000589; AllianceGenome:RGD:2325467
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rno-mir-322; rno-mir-322-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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See Mir322 in Genome Data Viewer
Location:
Xq36
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (137726147..137726241, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (132806594..132806688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (158148161..158148255)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550366 Neighboring gene microRNA 351 Neighboring gene microRNA 503 Neighboring gene placenta enriched 1 Neighboring gene PABIR family member 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats. Nemoto T, et al. Sci Rep, 2020 Jan 28. PMID 31992823, Free PMC Article
  2. MicroRNA-322-5p protects against myocardial infarction through targeting BTG2. Ruan Y, et al. Am J Med Sci, 2024 Jun. PMID 38437946
  3. miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat. Merlet E, et al. Cardiovasc Res, 2013 Jun 1. PMID 23447642, Free PMC Article
  4. Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis. Cao S, et al. Mol Biol Cell, 2014 Apr. PMID 24554769, Free PMC Article
  5. FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p. Zhang W, et al. Sci Rep, 2017 May 23. PMID 28536423, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-322-5p targeting Smurf2 regulates the TGF-beta/Smad pathway to protect cardiac function and inhibit myocardial infarction.
    Title: MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
  2. MicroRNA-322-5p protects against myocardial infarction through targeting BTG2.
    Title: MicroRNA-322-5p protects against myocardial infarction through targeting BTG2.
  3. CREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
    Title: CREB-binding protein and HIF-1α/β-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
  4. MiR-322-5p Alleviates Cell Injury and Impairment of Cognitive Function in Vascular Dementia by Targeting TSPAN5.
    Title: MiR-322-5p Alleviates Cell Injury and Impairment of Cognitive Function in Vascular Dementia by Targeting TSPAN5.
  5. Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
    Title: Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
  6. We found that insufficient intake of calories during pregnancy causes catch-up growth failure due to increased expression of miR-322 and decreased expression of GHR in the livers of offspring, and this effect is inherited by the next generation.
    Title: Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats.
  7. Suggest microRNA-424 as a new marker of disease progression in pulmonary arterial hypertension with a role in the development of right ventricular hypertrophy by targeting SMURF1 expression.
    Title: MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
  8. Data show that family with sequence similarity 3, member B protein (FAM3B) inhibited miR-322-5p expression, and enforced expression of miR-322-5p antagonized FAM3B-induced vascular smooth muscle cells (VSMCs) proliferation and migration.
    Title: FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.
  9. miR-322/503 represses Smurf2 translation, in turn affecting intestinal epithelial homeostasis by altering TGF-beta/Smad2 signaling and intestinal epithelial cell apoptosis.
    Title: Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis.
  10. Demonstrate that miR-424/322 is up-regulated after vascular injury. This is likely an adaptive response to counteract smooth muscle cell proliferation.
    Title: miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat.
Submit: New GeneRIF Correction

Markers

Other Names

  • microRNA mir-322
  • microRNA mir-322-2

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA base-pairing post-transcriptional repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_031768.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    137726147..137726241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials