Mir145 microRNA 145 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mir145provided by RGD
Official Full Name: microRNA 145provided by RGD
Primary source: RGD:2325565
See related: miRBase:MI0000918; AllianceGenome:RGD:2325565
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rno-mir-145
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 18q12.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (57369983..57370070, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (55099640..55099727, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (56969907..56969994, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00707 inhibits myocardial fibrosis and immune disorder in rheumatic heart disease by regulating miR-145-5p/S1PR1.
Title: LINC00707 inhibits myocardial fibrosis and immune disorder in rheumatic heart disease by regulating miR-145-5p/S1PR1.
[Involvement of microRNA-145/TGF-beta in the regulation of swimming exercise on vascular calcification in type 2 diabetic rats].
Title: [Involvement of microRNA-145/TGF-β in the regulation of swimming exercise on vascular calcification in type 2 diabetic rats].
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells.
Title: N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells.
Tempol attenuates chronic intermittent hypoxia-induced lung injury through the miR-145-5p/Nrf2 signaling pathway.
Title: Tempol attenuates chronic intermittent hypoxia-induced lung injury through the miR-145-5p/Nrf2 signaling pathway.
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles improve ovarian function in rats with primary ovarian insufficiency by carrying miR-145-5p.
Title: Human umbilical cord mesenchymal stem cell-derived extracellular vesicles improve ovarian function in rats with primary ovarian insufficiency by carrying miR-145-5p.
MicroRNA-145 and microRNA-486 are potential serum biomarkers for vascular calcification.
Title: MicroRNA-145 and microRNA-486 are potential serum biomarkers for vascular calcification.
Effects of miR-145-5p on cardiomyocyte proliferation and apoptosis, GIGYF1 expression and oxidative stress response in rats with myocardial ischemia-reperfusion.
Title: Effects of miR-145-5p on cardiomyocyte proliferation and apoptosis, GIGYF1 expression and oxidative stress response in rats with myocardial ischemia-reperfusion.
microRNA-145-5p attenuates acute lung injury via targeting ETS2.
Title: microRNA-145-5p attenuates acute lung injury via targeting ETS2.
miR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection.
Title: miR-145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection.
Modulation of miR-145-5p and miR-146b-5p levels is linked to reduced parasite load in H9C2 Trypanosoma cruzi infected cardiomyoblasts.
Title: Modulation of miR-145-5p and miR-146b-5p levels is linked to reduced parasite load in H9C2 Trypanosoma cruzi infected cardiomyoblasts.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA base-pairing translational repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta smooth muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac vascular smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroperoxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in ectodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-16 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of somatic stem cell division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RISC complex	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.