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ANKRD61 ankyrin repeat domain 61 [ Homo sapiens (human) ]

Gene ID: 100310846, updated on 7-Apr-2025

Summary

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Official Symbol
ANKRD61provided by HGNC
Official Full Name
ankyrin repeat domain 61provided by HGNC
Primary source
HGNC:HGNC:22467
See related
Ensembl:ENSG00000157999 AllianceGenome:HGNC:22467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in testis (RPKM 3.5), bone marrow (RPKM 1.7) and 12 other tissues See more
Orthologs
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Genomic context

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See ANKRD61 in Genome Data Viewer
Location:
7p22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6031376..6036552)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6149151..6154327)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6071007..6076183)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25615 Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6065935-6066435 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene Neighboring gene RNA, U6 small nuclear 218, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Ankyrins, multifunctional proteins involved in many cellular pathways. Hryniewicz-Jankowska A, et al. Folia Histochem Cytobiol, 2002. PMID 12219834
  2. The ankyrin repeat: a diversity of interactions on a common structural framework. Sedgwick SG, et al. Trends Biochem Sci, 1999 Aug. PMID 10431175
  3. The ankyrin repeat as molecular architecture for protein recognition. Mosavi LK, et al. Protein Sci, 2004 Jun. PMID 15152081, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Ankyrin repeat: a unique motif mediating protein-protein interactions. Li J, et al. Biochemistry, 2006 Dec 26. PMID 17176038

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271700.2 → NP_001258629.1  ankyrin repeat domain-containing protein 61

    See identical proteins and their annotated locations for NP_001258629.1

    Status: VALIDATED

    Source sequence(s)
    AC005995, AI221268
    Consensus CDS
    CCDS64590.1
    UniProtKB/Swiss-Prot
    A6NGH8
    Related
    ENSP00000386502.1, ENST00000409061.2
    Conserved Domains (5) summary
    cd00204
    Location:166 → 298
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:172 → 275
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:263 → 317
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:169 → 198
    ANK; ANK repeat [structural motif]
    cl02529
    Location:32 → 115
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6031376..6036552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6149151..6154327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NGH8.2 GenPept UniProtKB/Swiss-Prot:A6NGH8

Gene LinkOut

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