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IL2 interleukin 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100302458, updated on 2-Dec-2024
Gene symbol
IL2
Gene description
interleukin 2
See related
Ensembl:ENSOCUG00000010100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
TCGF
Orthologs
human mouse all
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See IL2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 8 NC_091439.1 (42183324..42188476)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 15 NC_067388.1 (95180093..95185241, complement)

Chromosome 8 - NC_091439.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108178069 Neighboring gene interleukin 21 Neighboring gene adenosine deaminase domain containing 1 Neighboring gene bridge-like lipid transfer protein family member 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [Role of interleukin 2 on apoptosis of lens epithelium cells in intraocular non-infective inflammation induced by iron]. Li XM, et al. Zhonghua Yan Ke Za Zhi, 2007 Oct. PMID 18201527
  2. The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus). Perkins HD, et al. Cytokine, 2000 Jun. PMID 10843729
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-2 activates the STAT3 pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
    Title: [Role of interleukin 2 on apoptosis of lens epithelium cells in intraocular non-infective inflammation induced by iron].
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-2 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-2
Names
T-cell growth factor
patial sequence of Interleukin-2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163180.1 → NP_001156652.1  interleukin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156652.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF068057
    UniProtKB/Swiss-Prot
    O77620, Q0MS71
    UniProtKB/TrEMBL
    A0A0N9HFH0, A0A0N9HRS8, A5YT96
    Related
    ENSOCUP00000008701.2, ENSOCUT00000010098.2
    Conserved Domains (1) summary
    pfam00715
    Location:7 → 149
    IL2; Interleukin 2

  2. NM_001171099.1 → NP_001164570.1  interleukin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164570.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AF169168
    UniProtKB/TrEMBL
    A5YT96, Q9MZR9
    Related
    ENSOCUP00000041258.1, ENSOCUT00000041329.1
    Conserved Domains (1) summary
    cl23879
    Location:7 → 129
    IL2; Interleukin 2

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091439.1 Reference mOryCun1.1

    Range
    42183324..42188476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77620.1 GenPept UniProtKB/Swiss-Prot:O77620

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials