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Mettl9 methyltransferase 9, His-X-His N1(pi)-histidine [ Rattus norvegicus (Norway rat) ]

Gene ID: 100302453, updated on 10-Feb-2026
Official Symbol
Mettl9provided by RGD
Official Full Name
methyltransferase 9, His-X-His N1(pi)-histidineprovided by RGD
Primary source
RGD:2311609
See related
Ensembl:ENSRNOG00000025940 AllianceGenome:RGD:2311609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-L-histidine N-pros-methyltransferase activity. Predicted to be active in endoplasmic reticulum and mitochondrion. Orthologous to human METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 157.9), Adrenal (RPKM 123.3) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Mettl9 in Genome Data Viewer
Location:
1q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185006953..185054359)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175575805..175623065)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (190962935..191009926)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene U6 spliceosomal RNA Neighboring gene immunoglobulin superfamily, member 6 Neighboring gene otoancorin Neighboring gene uncharacterized LOC108349630

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. Huang C, et al. J Neuroinflammation, 2023 Feb 17. PMID 36803376, Free PMC Article
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.
    Title: Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-L-histidine N-pros-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-L-histidine N-pros-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-L-histidine N-pros-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
protein-L-histidine N-pros-methyltransferase
Names
methyltransferase 9, His-X-His N1-histidine
methyltransferase like 9
methyltransferase-like protein 9
NP_001156636.1
XP_006230216.1
XP_008757880.1
XP_008757881.1
XP_063140139.1
XP_063140378.1
XP_063140645.1
XP_063140947.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163164.1 → NP_001156636.1  protein-L-histidine N-pros-methyltransferase

    See identical proteins and their annotated locations for NP_001156636.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I8T8, G0Z7P9
    Conserved Domains (1) summary
    pfam05219
    Location:56 → 317
    DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    185006953..185054359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759659.4 → XP_008757881.1  protein-L-histidine N-pros-methyltransferase isoform X3

    UniProtKB/TrEMBL
    G0Z7P9
    Conserved Domains (1) summary
    pfam05219
    Location:16 → 277
    DREV; DREV methyltransferase

  2. XM_063284069.1 → XP_063140139.1  protein-L-histidine N-pros-methyltransferase isoform X4

    UniProtKB/TrEMBL
    G0Z7P9

  3. XM_006230154.4 → XP_006230216.1  protein-L-histidine N-pros-methyltransferase isoform X1

    UniProtKB/TrEMBL
    D3ZZ04, G0Z7P9
    Related
    ENSRNOP00000037064.4, ENSRNOT00000039186.5
    Conserved Domains (1) summary
    pfam05219
    Location:56 → 316
    DREV; DREV methyltransferase

  4. XM_063284308.1 → XP_063140378.1  protein-L-histidine N-pros-methyltransferase isoform X5

  5. XM_063284877.1 → XP_063140947.1  protein-L-histidine N-pros-methyltransferase isoform X7

  6. XM_008759658.3 → XP_008757880.1  protein-L-histidine N-pros-methyltransferase isoform X2

    UniProtKB/TrEMBL
    A0ABK0L1J4, A6I8T9
    Related
    ENSRNOP00000102286.1, ENSRNOT00000141315.1
    Conserved Domains (1) summary
    cl17173
    Location:56 → 251
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_063284575.1 → XP_063140645.1  protein-L-histidine N-pros-methyltransferase isoform X6

    UniProtKB/TrEMBL
    C3VPW1
Nucleotide Protein Strain
Heading Accession and Version

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