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NPVF neuropeptide VF precursor [ Sus scrofa (pig) ]

Gene ID: 100302024, updated on 8-Mar-2024

Summary

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Official Symbol
NPVFprovided by VGNC
Official Full Name
neuropeptide VF precursorprovided by VGNC
Primary source
VGNC:VGNC:90864
See related
Ensembl:ENSSSCG00000036611
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
RFRP
Expression
Low expression observed in reference dataset See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (47082678..47087651)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (51890546..51895218, complement)

Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102164754 Neighboring gene uncharacterized LOC102165006 Neighboring gene uncharacterized LOC110257556 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene mitochondrial carrier homolog 2 pseudogene Neighboring gene sperm microtubule inner protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Effect of RFRP-3, the mammalian ortholog of GnIH, on apoptosis and autophagy in porcine ovarian granulosa cells via the p38MAPK pathway. Zhang X, et al. Theriogenology, 2022 Mar 1. PMID 34973645
  2. Identification and characterization of RFRP gene in pigs and its association with reproductive traits. Fang MX, et al. Genet Mol Res, 2014 Jan 14. PMID 24446341
  3. The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro. Li X, et al. Mol Cell Endocrinol, 2013 Jun 15. PMID 23541949
  4. Relationship of neuropeptide FF receptors with pubertal maturation of gilts. Thorson JF, et al. Biol Reprod, 2017 Mar 1. PMID 28339619
  5. Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle. Li X, et al. Peptides, 2012 Aug. PMID 22664321

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of RFRP-3, the mammalian ortholog of GnIH, on apoptosis and autophagy in porcine ovarian granulosa cells via the p38MAPK pathway.
    Title: Effect of RFRP-3, the mammalian ortholog of GnIH, on apoptosis and autophagy in porcine ovarian granulosa cells via the p38MAPK pathway.
  2. The RFRP neurons in the porcine hypothalamus were localized in the paraventricular and dorsomedial nuclei with RFRP fibers in the lateral hypothalamic area.
    Title: Relationship of neuropeptide FF receptors with pubertal maturation of gilts.
  3. In conclusion, the pig RFRP gene was cloned and characterized in this study, and its polymorphism g.45859759C>T showed significant associations with reproductive traits.
    Title: Identification and characterization of RFRP gene in pigs and its association with reproductive traits.
  4. RFRP-3 inhibited the release and synthesis of gonadotrophin releasing hormone, gonadotrophin and steroid hormones.
    Title: The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gonadotropin secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: pro-FMRFamide-related neuropeptide VF
Names
RFamide-related peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

    Range
    47082678..47087651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013985789.2 → XP_013841243.2  LOW QUALITY PROTEIN: pro-FMRFamide-related neuropeptide VF

    UniProtKB/TrEMBL
    A0A8D1BRN9
    Related
    ENSSSCP00000044769.1, ENSSSCT00000037223.1
Nucleotide Protein
Heading Accession and Version

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