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CDH5 cadherin 5 [ Homo sapiens (human) ]

Gene ID: 1003, updated on 1-Aug-2020

Summary

Official Symbol
CDH5provided by HGNC
Official Full Name
cadherin 5provided by HGNC
Primary source
HGNC:HGNC:1764
See related
Ensembl:ENSG00000179776 MIM:601120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
7B4; CD144
Summary
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Expression
Biased expression in placenta (RPKM 108.8), lung (RPKM 57.5) and 12 other tissues See more
Orthologs

Genomic context

See CDH5 in Genome Data Viewer
Location:
16q21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66366657..66404784)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66400525..66438689)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371317 Neighboring gene RNA, 5S ribosomal pseudogene 428 Neighboring gene uncharacterized LOC105371318 Neighboring gene long intergenic non-protein coding RNA 920 Neighboring gene nuclear envelope phosphatase-regulatory subunit 1 pseudogene Neighboring gene brain expressed associated with NEDD4 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat C treated human brain microvascular endothelial cells result in downregulation and dissociation of VE-PTP and SHP2 from VE-cadherin PubMed
tat HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells PubMed
tat Treatment of human brain microvascular endothelial cells with HIV-1 Tat downregulates the expression of VE-cadherin, claudin-5, ZO-1, and occludin proteins in a dose- and time-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BMP receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrinogen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
vascular endothelial growth factor receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction organization IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction organization TAS
Traceable Author Statement
more info
 
bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
maintenance of permeability of blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vasculature development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cadherin-5
Names
7B4 antigen
VE-cadherin
cadherin 5, type 2 (vascular endothelium)
cadherin 5, type 2, VE-cadherin (vascular epithelium)
cd144 antigen
endothelial-specific cadherin
vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001795.5NP_001786.2  cadherin-5 preproprotein

    See identical proteins and their annotated locations for NP_001786.2

    Status: REVIEWED

    Source sequence(s)
    AB209908, BQ716387, X59796, X79981
    Consensus CDS
    CCDS10804.1
    UniProtKB/Swiss-Prot
    P33151
    UniProtKB/TrEMBL
    Q59EA3
    Related
    ENSP00000344115.3, ENST00000341529.8
    Conserved Domains (4) summary
    cd11304
    Location:156254
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79149
    CA; Cadherin repeats
    pfam00028
    Location:263364
    Cadherin; Cadherin domain
    pfam01049
    Location:633775
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66366657..66404784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522801.2XP_011521103.1  cadherin-5 isoform X1

    Conserved Domains (4) summary
    cd11304
    Location:156254
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79149
    CA; Cadherin repeats
    pfam00028
    Location:272373
    Cadherin; Cadherin domain
    pfam01049
    Location:635786
    Cadherin_C; Cadherin cytoplasmic region
  2. XM_024450133.1XP_024305901.1  cadherin-5 isoform X1

    Conserved Domains (4) summary
    cd11304
    Location:156254
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79149
    CA; Cadherin repeats
    pfam00028
    Location:272373
    Cadherin; Cadherin domain
    pfam01049
    Location:635786
    Cadherin_C; Cadherin cytoplasmic region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114117.1: Suppressed sequence

    Description
    NM_001114117.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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