MIP major intrinsic protein of lens fiber [Ovis aries (sheep)] - Gene

Summary

Gene symbol: MIP
Gene description: major intrinsic protein of lens fiber
See related: Ensembl:ENSOARG00020057131
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Ovis aries
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as: AQP0
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	ARS-UI_Ramb_v3.0 (GCF_016772045.2)	3	NC_056056.1 (163149657..163164617)

Chromosome 3 - NC_056056.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Ovis aries Rambouillet Genome sequencing and assembly
BioProject: PRJNA414087
Analysis date: Thu Jan 09 10:41:41 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0
Title: Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0.
electron crystallographic structure determination of the AQP0-mediated membrane junction, is reported.
Title: Effect of lipid head groups on double-layered two-dimensional crystals formed by aquaporin-0.
Through the online combination of size exclusion chromatography, small-angle X-ray scattering , and refractometry, the study determined a precise geometrical model of the n-dodecyl beta-d-maltopyranoside corona surrounding aquaporin-0.
Title: Modeling detergent organization around aquaporin-0 using small-angle X-ray scattering.
The first structural models of the supramolecular organization of AQP0 tetramers & connexon hexamers in junctional microdomains were generated by docking atomic models of AQP0 and connexons into the atomic force microscopy topographs.
Title: Structural models of the supramolecular organization of AQP0 and connexons in junctional microdomains.
1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals.
Title: Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.

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General gene information

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Markers

MARC_16767-16768:1033488277:1 (e-PCR)
- UniSTS:268107

MARC_16767-16768:1042841153:1 (e-PCR)
- UniSTS:268107

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables water channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lens fiber major intrinsic protein

Names: Aquaporin-0; aquaporin 0

NP_001153230.1

EC 1.11.1.6

XP_060267562.1

EC 1.11.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.