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ZNF783 zinc finger protein 783 [ Homo sapiens (human) ]

Gene ID: 100289678, updated on 13-May-2022

Summary

Official Symbol
ZNF783provided by HGNC
Official Full Name
zinc finger protein 783provided by HGNC
Primary source
HGNC:HGNC:27222
See related
Ensembl:ENSG00000204946 AllianceGenome:HGNC:27222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 4.3), lymph node (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF783 in Genome Data Viewer
Location:
7q36.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149262196..149284994)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150444011..150466766)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148959287..148982085)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 282 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene uncharacterized LOC124901769 Neighboring gene AI894139 pseudogene Neighboring gene tRNA-Cys (anticodon GCA) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12914, FLJ16713, DKFZp762P2111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 783
Names
protein ZNF783
zinc finger family member 783

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195220.2NP_001182149.1  zinc finger protein 783

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC004890
    Consensus CDS
    CCDS56519.1
    UniProtKB/Swiss-Prot
    Q6ZMS7
    Related
    ENSP00000410890.1, ENST00000434415.6
    Conserved Domains (8) summary
    cd07765
    Location:143182
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:143202
    KRAB; krueppel associated box
    COG5048
    Location:468516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438458
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:351371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468488
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:57112
    DUF3669; Zinc finger protein
    pfam13465
    Location:480505
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_144366.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004890
  2. NR_144367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004890

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149262196..149284994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419692.1XP_047275648.1  zinc finger protein 783 isoform X2

  2. XM_011515701.3XP_011514003.1  zinc finger protein 783 isoform X1

    Conserved Domains (8) summary
    cd07765
    Location:154193
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:154213
    KRAB; krueppel associated box
    COG5048
    Location:479527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479499
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:68123
    DUF3669; Zinc finger protein
    pfam13465
    Location:491516
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001744503.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150444011..150466766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)