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ZNF605 zinc finger protein 605 [ Homo sapiens (human) ]

Gene ID: 100289635, updated on 3-May-2025
Official Symbol
ZNF605provided by HGNC
Official Full Name
zinc finger protein 605provided by HGNC
Primary source
HGNC:HGNC:28068
See related
Ensembl:ENSG00000196458 AllianceGenome:HGNC:28068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, May 2025]
Annotation information
Note: ZNF605 was originally represented by geneID:90462, and is located at chromosome 12q24.33. For NCBI Build 36.3, geneID:90462 was misplaced on the unplaced chr 12 contig NT_167217.1, and geneID:100289635 was created to represent the chr 12 location. This error was fixed in September 2009 by renaming geneID:100289635 as ZNF605. [13 Feb 2013]
Expression
Ubiquitous expression in thyroid (RPKM 5.2), ovary (RPKM 3.1) and 25 other tissues See more
Orthologs
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See ZNF605 in Genome Data Viewer
Location:
12q24.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132918306..132956306, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132969080..133013678, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133494892..133532892, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26180 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5132 Neighboring gene uncharacterized LOC124903065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133531610-133532440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133532441-133533269 Neighboring gene uncharacterized LOC124903064 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133553507-133553757 Neighboring gene NANOGNB pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133563299-133563798 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: CHFR

Clone Names

  • FLJ14967, FLJ16520, DKFZp686B222, DKFZp451B1818

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 605

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164715.2NP_001158187.1  zinc finger protein 605 isoform 2

    See identical proteins and their annotated locations for NP_001158187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) includes an alternate segment, compared to isoform 1.
    Source sequence(s)
    AC127070, AK122878, BF476024
    Consensus CDS
    CCDS53850.1
    UniProtKB/Swiss-Prot
    Q86T29
    Related
    ENSP00000376135.3, ENST00000392321.3
    Conserved Domains (6) summary
    smart00349
    Location:765
    KRAB; krueppel associated box
    COG5048
    Location:199603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:230250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:620642
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:745
    KRAB; KRAB box
    pfam13465
    Location:551575
    zf-H2C2_2; Zinc-finger double domain
  2. NM_183238.4NP_899061.1  zinc finger protein 605 isoform 1

    See identical proteins and their annotated locations for NP_899061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC073911, AC127070, AL832191, BF476024
    Consensus CDS
    CCDS31938.1
    UniProtKB/Swiss-Prot
    B3KVG4, D3DXJ0, Q86T29, Q86T91
    Related
    ENSP00000353314.3, ENST00000360187.9
    Conserved Domains (6) summary
    smart00349
    Location:746
    KRAB; krueppel associated box
    COG5048
    Location:168572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:589611
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:745
    KRAB; KRAB box
    pfam13465
    Location:520544
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132918306..132956306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132969080..133013678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)