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ZNF605 zinc finger protein 605 [ Homo sapiens (human) ]

Gene ID: 100289635, updated on 1-Jun-2020

Summary

Official Symbol
ZNF605provided by HGNC
Official Full Name
zinc finger protein 605provided by HGNC
Primary source
HGNC:HGNC:28068
See related
Ensembl:ENSG00000196458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
Note: ZNF605 was originally represented by geneID:90462, and is located at chromosome 12q24.33. For NCBI Build 36.3, geneID:90462 was misplaced on the unplaced chr 12 contig NT_167217.1, and geneID:100289635 was created to represent the chr 12 location. This error was fixed in September 2009 by renaming geneID:100289635 as ZNF605. [13 Feb 2013]
Expression
Ubiquitous expression in thyroid (RPKM 5.2), ovary (RPKM 3.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF605 in Genome Data Viewer
Location:
12q24.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (132918306..132956306, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133498019..133532908, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928530 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) pseudogene Neighboring gene NANOGNB pseudogene 2 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CHFR

Homology

Clone Names

  • FLJ14967, FLJ16520, DKFZp686B222, DKFZp451B1818

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164715.2NP_001158187.1  zinc finger protein 605 isoform 2

    See identical proteins and their annotated locations for NP_001158187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) includes an alternate segment, compared to isoform 1.
    Source sequence(s)
    AC127070, AK122878, BF476024
    Consensus CDS
    CCDS53850.1
    UniProtKB/Swiss-Prot
    Q86T29
    Related
    ENSP00000376135.3, ENST00000392321.3
    Conserved Domains (6) summary
    smart00349
    Location:765
    KRAB; krueppel associated box
    COG5048
    Location:199603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:230250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:620642
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:745
    KRAB; KRAB box
    pfam13465
    Location:551575
    zf-H2C2_2; Zinc-finger double domain
  2. NM_183238.4NP_899061.1  zinc finger protein 605 isoform 1

    See identical proteins and their annotated locations for NP_899061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC073911, AC127070, AL832191, BF476024
    Consensus CDS
    CCDS31938.1
    UniProtKB/Swiss-Prot
    Q86T29
    Related
    ENSP00000353314.3, ENST00000360187.9
    Conserved Domains (6) summary
    smart00349
    Location:746
    KRAB; krueppel associated box
    COG5048
    Location:168572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:589611
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:745
    KRAB; KRAB box
    pfam13465
    Location:520544
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    132918306..132956306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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