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TMEM225B transmembrane protein 225B [ Homo sapiens (human) ]

Gene ID: 100289187, updated on 5-Jan-2022

Summary

Official Symbol
TMEM225Bprovided by HGNC
Official Full Name
transmembrane protein 225Bprovided by HGNC
Primary source
HGNC:HGNC:53075
See related
Ensembl:ENSG00000244219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS1-259H13.2
Summary
Predicted to be involved in negative regulation of phosphatase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 71.2) See more
Orthologs
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Genomic context

See TMEM225B in Genome Data Viewer
Location:
7q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99572366..99611045)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99195890..99208668)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 3 pseudogene Neighboring gene uncharacterized LOC105375422 Neighboring gene family with sequence similarity 200 member A Neighboring gene zinc finger protein 655 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A5 promoter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 225B
Names
transmembrane protein 225-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195541.3NP_001182470.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AA781117, DB462723, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Related
    ENSP00000492416.1, ENST00000431679.6
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  2. NM_001195542.3NP_001182471.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AI028251, BG461486, DB456868, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  3. NM_001195543.3NP_001182472.1  transmembrane protein 225B

    See identical proteins and their annotated locations for NP_001182472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AA781117, AI028251, BI559535, DB477974, HY200726
    Consensus CDS
    CCDS87525.1
    UniProtKB/Swiss-Prot
    P0DP42
    Related
    ENSP00000491691.1, ENST00000453227.5
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99572366..99611045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011629.2XP_016867118.1  transmembrane protein 225B isoform X2

  2. XM_011515700.3XP_011514002.1  transmembrane protein 225B isoform X3

    See identical proteins and their annotated locations for XP_011514002.1

    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  3. XM_005250088.5XP_005250145.1  transmembrane protein 225B isoform X3

    See identical proteins and their annotated locations for XP_005250145.1

    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  4. XM_024446624.1XP_024302392.1  transmembrane protein 225B isoform X3

  5. XM_011515696.2XP_011513998.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513998.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  6. XM_011515699.2XP_011514001.1  transmembrane protein 225B isoform X3

    See identical proteins and their annotated locations for XP_011514001.1

    UniProtKB/Swiss-Prot
    P0DP42
    Conserved Domains (1) summary
    cl21598
    Location:26170
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  7. XM_024446622.1XP_024302390.1  transmembrane protein 225B isoform X2

  8. XM_024446625.1XP_024302393.1  transmembrane protein 225B isoform X3

  9. XM_011515697.1XP_011513999.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513999.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  10. XM_011515691.2XP_011513993.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513993.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  11. XM_011515692.2XP_011513994.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513994.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  12. XM_011515695.2XP_011513997.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513997.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  13. XM_011515694.2XP_011513996.1  transmembrane protein 225B isoform X2

    See identical proteins and their annotated locations for XP_011513996.1

    Conserved Domains (1) summary
    cl21598
    Location:41185
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  14. XM_024446623.1XP_024302391.1  transmembrane protein 225B isoform X3

  15. XM_024446621.1XP_024302389.1  transmembrane protein 225B isoform X1

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