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CLDN34 claudin 34 [ Homo sapiens (human) ]

Gene ID: 100288814, updated on 22-Sep-2022

Summary

Official Symbol
CLDN34provided by HGNC
Official Full Name
claudin 34provided by HGNC
Primary source
HGNC:HGNC:51259
See related
Ensembl:ENSG00000234469 AllianceGenome:HGNC:51259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be integral component of membrane. Predicted to be active in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CLDN34 in Genome Data Viewer
Location:
Xp22.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (9967358..9968352)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (9549941..9550935)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (9935398..9936392)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene shroom family member 2 Neighboring gene Sharpr-MPRA regulatory region 9039 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 33 Neighboring gene WWC family member 3 Neighboring gene Sharpr-MPRA regulatory region 7563 Neighboring gene chloride voltage-gated channel 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195081.2NP_001182010.1  claudin-34

    See identical proteins and their annotated locations for NP_001182010.1

    Status: VALIDATED

    Source sequence(s)
    AC002365
    Consensus CDS
    CCDS75951.1
    UniProtKB/Swiss-Prot
    H7C241
    Related
    ENSP00000403980.3, ENST00000445307.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    9967358..9968352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    9549941..9550935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)