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LIMS4 LIM zinc finger domain containing 4 [ Homo sapiens (human) ]

Gene ID: 100288695, updated on 2-Apr-2018

Summary

Official Symbol
LIMS4provided by HGNC
Official Full Name
LIM zinc finger domain containing 4provided by HGNC
Primary source
HGNC:HGNC:39941
See related
Ensembl:ENSG00000256671 Vega:OTTHUMG00000169984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIMS3L
Expression
Ubiquitous expression in endometrium (RPKM 15.2), adrenal (RPKM 6.4) and 24 other tissues See more

Genomic context

See LIMS4 in Genome Data Viewer
Location:
2q13
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (110386341..110473075, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111194191..111230652, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 532 pseudogene Neighboring gene long intergenic non-protein coding RNA 1106 Neighboring gene zinc finger and BTB domain containing 45 pseudogene 2 Neighboring gene glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) pseudogene Neighboring gene glycosylphosphatidylinositol anchor attachment 1 pseudogene 2 Neighboring gene uncharacterized LOC105373552 Neighboring gene uncharacterized LOC102724875 Neighboring gene RANBP2-like and GRIP domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General protein information

Preferred Names
LIM and senescent cell antigen-like-containing domain protein 4
Names
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like-containing domain protein 3-like
LIM-type zinc finger domains 4
particularly interesting new Cys-His protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205288.1NP_001192217.1  LIM and senescent cell antigen-like-containing domain protein 4

    See identical proteins and their annotated locations for NP_001192217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AA609556, AC108938
    Consensus CDS
    CCDS54387.1
    UniProtKB/Swiss-Prot
    P0CW19, P0CW20
    Related
    ENSP00000404432.2, ENST00000413601.3
    Conserved Domains (1) summary
    cl02475
    Location:72114
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

  1. NR_038099.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes multiple additional 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC108938, AC112229

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    110386341..110473075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003105.2XP_016858594.1  LIM and senescent cell antigen-like-containing domain protein 4 isoform X4

  2. XM_017003104.2XP_016858593.1  LIM and senescent cell antigen-like-containing domain protein 4 isoform X3

  3. XM_017003103.2XP_016858592.1  LIM and senescent cell antigen-like-containing domain protein 4 isoform X2

  4. XM_005263563.5XP_005263620.1  LIM and senescent cell antigen-like-containing domain protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YXC7
    Related
    ENSP00000488340.1, OTTHUMP00000280612, ENST00000632897.1
    Conserved Domains (5) summary
    cd09331
    Location:72130
    LIM1_PINCH; The first LIM domain of protein PINCH
    cd09332
    Location:133184
    LIM2_PINCH; The second LIM domain of protein PINCH
    cd09333
    Location:197247
    LIM3_PINCH; The third LIM domain of protein PINCH
    cd09334
    Location:253306
    LIM4_PINCH; The fourth LIM domain of protein PINCH
    cd09335
    Location:314367
    LIM5_PINCH; The fifth LIM domain of protein PINCH
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