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ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope [ Homo sapiens (human) ]

Gene ID: 100288413, updated on 18-Aug-2020

Summary

Official Symbol
ERVMER34-1provided by HGNC
Official Full Name
endogenous retrovirus group MER34 member 1, envelopeprovided by HGNC
Primary source
HGNC:HGNC:42970
See related
Ensembl:ENSG00000226887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEMO; envMER34
Expression
Biased expression in placenta (RPKM 6.1), kidney (RPKM 1.4) and 8 other tissues See more
Orthologs

Genomic context

See ERVMER34-1 in Genome Data Viewer
Location:
4q12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (52742553..52751425, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (53609684..53617807, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 4449 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene uncharacterized LOC107986281 Neighboring gene long intergenic non-protein coding RNA 1618 Neighboring gene Sharpr-MPRA regulatory region 13979 Neighboring gene RAS like family 11 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ12684, FLJ37999, MGC79429, MGC79431, MGC79432

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endogenous retroviral envelope protein HEMO
Names
HERV-MER_4q12 provirus ancestral Env polyprotein
LP9056 protein
endogenous MER34 (medium-reiteration-frequency-family-34) ORF
endogenous retrovirus group MER34 member 1 Env polyprotein
endogenous retrovirus group MER34, member 1
human endogenous MER34 ORF

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242690.2NP_001229619.1  endogenous retroviral envelope protein HEMO precursor

    See identical proteins and their annotated locations for NP_001229619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104066, AY189288, DA633167
    UniProtKB/Swiss-Prot
    Q9H9K5
    Related
    ENSP00000460602.1, ENST00000443173.6
    Conserved Domains (1) summary
    cl02885
    Location:401463
    Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)
  2. NM_024534.6NP_078810.1  endogenous retroviral envelope protein HEMO precursor

    See identical proteins and their annotated locations for NP_078810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104066, AY189288, BC067526, BP871936
    UniProtKB/Swiss-Prot
    Q9H9K5
    Related
    ENSP00000460255.1, ENST00000440542.1
    Conserved Domains (1) summary
    cl02885
    Location:401463
    Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    52742553..52751425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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