U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope [ Homo sapiens (human) ]

Gene ID: 100288413, updated on 22-Sep-2022

Summary

Official Symbol
ERVMER34-1provided by HGNC
Official Full Name
endogenous retrovirus group MER34 member 1, envelopeprovided by HGNC
Primary source
HGNC:HGNC:42970
See related
Ensembl:ENSG00000226887 AllianceGenome:HGNC:42970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEMO; envMER34
Summary
Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta (RPKM 6.1), kidney (RPKM 1.4) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ERVMER34-1 in Genome Data Viewer
Location:
4q12
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (52742553..52751425, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56229442..56238314, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (53608720..53617592, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 4449 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene small nucleolar RNA SNORA26 Neighboring gene uncharacterized LOC107986281 Neighboring gene long intergenic non-protein coding RNA 1618 Neighboring gene uncharacterized LOC124900700

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12684, FLJ37999, MGC79429, MGC79431, MGC79432

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endogenous retroviral envelope protein HEMO
Names
HERV-MER_4q12 provirus ancestral Env polyprotein
LP9056 protein
endogenous MER34 (medium-reiteration-frequency-family-34) ORF
endogenous retrovirus group MER34 member 1 Env polyprotein
endogenous retrovirus group MER34, member 1
human endogenous MER34 ORF

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242690.2NP_001229619.1  endogenous retroviral envelope protein HEMO precursor

    See identical proteins and their annotated locations for NP_001229619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104066, AY189288, DA633167
    UniProtKB/Swiss-Prot
    Q6NWN0, Q9H9K5
    Related
    ENSP00000460602.1, ENST00000443173.6
    Conserved Domains (1) summary
    cl02885
    Location:401463
    Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)
  2. NM_024534.6NP_078810.1  endogenous retroviral envelope protein HEMO precursor

    See identical proteins and their annotated locations for NP_078810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104066, AY189288, BC067526, BP871936
    UniProtKB/Swiss-Prot
    Q6NWN0, Q9H9K5
    Related
    ENSP00000460255.1, ENST00000440542.1
    Conserved Domains (1) summary
    cl02885
    Location:401463
    Ebola_HIV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    52742553..52751425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    56229442..56238314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)