Format

Send to:

Choose Destination

TIMM23 translocase of inner mitochondrial membrane 23 [ Homo sapiens (human) ]

Gene ID: 100287932, updated on 24-Nov-2020

Summary

Official Symbol
TIMM23provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 23provided by HGNC
Primary source
HGNC:HGNC:17312
See related
Ensembl:ENSG00000265354 MIM:605034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM23
Summary
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 39.1), heart (RPKM 22.4) and 25 other tissues See more
Orthologs

Genomic context

See TIMM23 in Genome Data Viewer
Location:
10q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (45972489..46003742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51592080..51623386, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene PARGP1-AGAP4 readthrough Neighboring gene RNA, 5S ribosomal pseudogene 310 Neighboring gene poly(ADP-ribose) glycohydrolase pseudogene 1 Neighboring gene ribosomal protein L35a pseudogene 23 Neighboring gene small nucleolar RNA, H/ACA box 74C-1 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene nuclear receptor coactivator 4 Neighboring gene uncharacterized LOC105378287 Neighboring gene microseminoprotein beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40725, FLJ56773, FLJ57459, FLJ79448, MGC71995, MGC87383

Gene Ontology Provided by GOA

Function Evidence Code Pubs
P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim23
Names
translocase of inner mitochondrial membrane 23 homolog
translocase of the inner mitochondrial membrane

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032850.2 RefSeqGene

    Range
    5037..36290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006327.4NP_006318.1  mitochondrial import inner membrane translocase subunit Tim23

    See identical proteins and their annotated locations for NP_006318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    BC062707, BC066951, BU619060
    Consensus CDS
    CCDS73091.1
    UniProtKB/Swiss-Prot
    O14925
    Related
    ENSP00000464522.3, ENST00000580018.4
    Conserved Domains (1) summary
    TIGR00983
    Location:46191
    3a0801s02tim23; mitochondrial import inner membrane translocase subunit tim23

RNA

  1. NR_073029.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1 and represents the longest transcript. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC062707, BU619060, CD514420
  2. NR_073030.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC062707, BU619060, BY799488

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    45972489..46003742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center