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WASHC1 WASH complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 100287171, updated on 26-Oct-2022

Summary

Official Symbol
WASHC1provided by HGNC
Official Full Name
WASH complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24361
See related
Ensembl:ENSG00000181404 MIM:613632; AllianceGenome:HGNC:24361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WASH; WASH1; FAM39E
Summary
Enables alpha-tubulin binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; endosomal transport; and positive regulation of pseudopodium assembly. Located in early endosome. Part of WASH complex. Colocalizes with exocyst. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 16.3), spleen (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

See WASHC1 in Genome Data Viewer
Location:
9p24.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14513..30487, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (8314..23877, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14513..29739, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DEAD/H-box helicase 11 like 5 (pseudogene) Neighboring gene microRNA 1302-9 Neighboring gene family with sequence similarity 138 member C Neighboring gene protein piccolo-like Neighboring gene PGM5P3 antisense RNA 1 Neighboring gene phosphoglucomutase 5 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00038, FLJ75027, FLJ99609, MGC190539, MGC193256, DKFZp434K1323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosomal transport IC
Inferred by Curator
more info
PubMed 
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IC
Inferred by Curator
more info
PubMed 
involved_in regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of WASH complex IC
Inferred by Curator
more info
PubMed 
part_of WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IC
Inferred by Curator
more info
PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WASH complex subunit 1
Names
CXYorf1-like protein on chromosome 9
FLJ00075 protein
WAS protein family homolog 1
actin nucleation promoting factor
family with sequence similarity 39, member E

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378090.1NP_001365019.1  WASH complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AL928970
    Consensus CDS
    CCDS78375.1
    UniProtKB/Swiss-Prot
    A8K0Z3
    Related
    ENSP00000512441.1, ENST00000696149.1
    Conserved Domains (1) summary
    pfam11945
    Location:14297
    WASH_WAHD; WAHD domain of WASH complex
  2. NM_182905.6NP_878908.4  WASH complex subunit 1

    See identical proteins and their annotated locations for NP_878908.4

    Status: VALIDATED

    Source sequence(s)
    AL928970
    Consensus CDS
    CCDS78375.1
    UniProtKB/Swiss-Prot
    A8K0Z3
    Related
    ENSP00000485627.1, ENST00000442898.5
    Conserved Domains (1) summary
    pfam11945
    Location:14297
    WASH_WAHD; WAHD domain of WASH complex

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    14513..30487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517666.3XP_011515968.1  WASH complex subunit 1 isoform X8

    Conserved Domains (1) summary
    pfam11945
    Location:63272
    WASH_WAHD; WAHD domain of WASH complex
  2. XM_011517660.3XP_011515962.1  WASH complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam11945
    Location:58305
    WASH_WAHD; WAHD domain of WASH complex
  3. XM_011517659.3XP_011515961.1  WASH complex subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam11945
    Location:59306
    WASH_WAHD; WAHD domain of WASH complex
  4. XM_047422581.1XP_047278537.1  WASH complex subunit 1 isoform X9

  5. XM_017014171.2XP_016869660.1  WASH complex subunit 1 isoform X9

    Conserved Domains (1) summary
    pfam11945
    Location:130200
    WASH_WAHD; WAHD domain of WASH complex
  6. XM_011517662.4XP_011515964.1  WASH complex subunit 1 isoform X4

    Conserved Domains (1) summary
    pfam11945
    Location:49296
    WASH_WAHD; WAHD domain of WASH complex
  7. XM_024447369.2XP_024303137.1  WASH complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    A8K0Z3
    Conserved Domains (1) summary
    pfam11945
    Location:14297
    WASH_WAHD; WAHD domain of WASH complex
  8. XM_017014172.2XP_016869661.1  WASH complex subunit 1 isoform X9

    Conserved Domains (1) summary
    pfam11945
    Location:130200
    WASH_WAHD; WAHD domain of WASH complex
  9. XM_047422579.1XP_047278535.1  WASH complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    A8K0Z3
  10. XM_011517664.4XP_011515966.1  WASH complex subunit 1 isoform X6

    Conserved Domains (1) summary
    pfam11945
    Location:40283
    WASH_WAHD; WAHD domain of WASH complex
  11. XM_017014169.2XP_016869658.1  WASH complex subunit 1 isoform X5

    Conserved Domains (1) summary
    pfam11945
    Location:40284
    WASH_WAHD; WAHD domain of WASH complex
  12. XM_011517665.3XP_011515967.1  WASH complex subunit 1 isoform X7

    Conserved Domains (1) summary
    pfam11945
    Location:25273
    WASH_WAHD; WAHD domain of WASH complex
  13. XM_047422587.1XP_047278543.1  WASH complex subunit 1 isoform X15

  14. XM_047422584.1XP_047278540.1  WASH complex subunit 1 isoform X12

  15. XM_047422583.1XP_047278539.1  WASH complex subunit 1 isoform X11

  16. XM_047422582.1XP_047278538.1  WASH complex subunit 1 isoform X10

  17. XM_047422586.1XP_047278542.1  WASH complex subunit 1 isoform X14

  18. XM_047422585.1XP_047278541.1  WASH complex subunit 1 isoform X13

  19. XM_047422588.1XP_047278544.1  WASH complex subunit 1 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    8314..23877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)