Format

Send to:

Choose Destination

WASHC1 WASH complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 100287171, updated on 17-Jun-2019

Summary

Official Symbol
WASHC1provided by HGNC
Official Full Name
WASH complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24361
See related
Ensembl:ENSG00000181404 MIM:613632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WASH; WASH1; FAM39E
Expression
Ubiquitous expression in skin (RPKM 16.3), spleen (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See WASHC1 in Genome Data Viewer
Location:
9p24.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (14475..30487, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14469..29739, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DEAD/H-box helicase 11 like 5 Neighboring gene uncharacterized LOC107987041 Neighboring gene microRNA 1302-9 Neighboring gene family with sequence similarity 138 member C Neighboring gene PGM5P3 antisense RNA 1 Neighboring gene phosphoglucomutase 5 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00038, FLJ75027, FLJ99609, MGC190539, MGC193256, DKFZp434K1323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
centriole IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with exocyst IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WASH complex subunit 1
Names
CXYorf1-like protein on chromosome 9
FLJ00075 protein
WAS protein family homolog 1
actin nucleation promoting factor
family with sequence similarity 39, member E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182905.5NP_878908.4  WASH complex subunit 1

    See identical proteins and their annotated locations for NP_878908.4

    Status: VALIDATED

    Source sequence(s)
    AL928970
    Consensus CDS
    CCDS78375.1
    UniProtKB/Swiss-Prot
    A8K0Z3
    Related
    ENSP00000485627.1, ENST00000442898.5
    Conserved Domains (1) summary
    pfam11945
    Location:14297
    WASH_WAHD; WAHD domain of WASH complex

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    14475..30487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517666.2XP_011515968.1  WASH complex subunit 1 isoform X9

    Conserved Domains (1) summary
    pfam11945
    Location:63272
    WASH_WAHD; WAHD domain of WASH complex
  2. XM_011517660.2XP_011515962.1  WASH complex subunit 1 isoform X3

    Conserved Domains (1) summary
    pfam11945
    Location:58305
    WASH_WAHD; WAHD domain of WASH complex
  3. XM_011517659.2XP_011515961.1  WASH complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam11945
    Location:59306
    WASH_WAHD; WAHD domain of WASH complex
  4. XM_011517658.2XP_011515960.1  WASH complex subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam11945
    Location:28311
    WASH_WAHD; WAHD domain of WASH complex
  5. XM_017014171.1XP_016869660.1  WASH complex subunit 1 isoform X10

    Conserved Domains (1) summary
    pfam11945
    Location:130200
    WASH_WAHD; WAHD domain of WASH complex
  6. XM_011517662.3XP_011515964.1  WASH complex subunit 1 isoform X5

    Conserved Domains (1) summary
    pfam11945
    Location:49296
    WASH_WAHD; WAHD domain of WASH complex
  7. XM_024447369.1XP_024303137.1  WASH complex subunit 1 isoform X4

    Conserved Domains (1) summary
    pfam11945
    Location:14297
    WASH_WAHD; WAHD domain of WASH complex
  8. XM_017014172.1XP_016869661.1  WASH complex subunit 1 isoform X10

    Conserved Domains (1) summary
    pfam11945
    Location:130200
    WASH_WAHD; WAHD domain of WASH complex
  9. XM_011517664.3XP_011515966.1  WASH complex subunit 1 isoform X7

    Conserved Domains (1) summary
    pfam11945
    Location:40283
    WASH_WAHD; WAHD domain of WASH complex
  10. XM_011517663.3XP_011515965.1  WASH complex subunit 1 isoform X6

    Conserved Domains (1) summary
    pfam11945
    Location:40284
    WASH_WAHD; WAHD domain of WASH complex
  11. XM_024447370.1XP_024303138.1  WASH complex subunit 1 isoform X11

    Conserved Domains (1) summary
    pfam11945
    Location:196
    WASH_WAHD; WAHD domain of WASH complex
  12. XM_017014170.1XP_016869659.1  WASH complex subunit 1 isoform X7

    Conserved Domains (1) summary
    pfam11945
    Location:40283
    WASH_WAHD; WAHD domain of WASH complex
  13. XM_017014169.1XP_016869658.1  WASH complex subunit 1 isoform X6

    Conserved Domains (1) summary
    pfam11945
    Location:40284
    WASH_WAHD; WAHD domain of WASH complex
  14. XM_011517665.2XP_011515967.1  WASH complex subunit 1 isoform X8

    Conserved Domains (1) summary
    pfam11945
    Location:25273
    WASH_WAHD; WAHD domain of WASH complex
  15. XM_017014173.1XP_016869662.1  WASH complex subunit 1 isoform X12

RNA

  1. XR_002956737.1 RNA Sequence

  2. XR_929142.2 RNA Sequence

  3. XR_002956738.1 RNA Sequence

  4. XR_002956739.1 RNA Sequence

  5. XR_002956740.1 RNA Sequence

  6. XR_002956741.1 RNA Sequence

Support Center