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RASA4B RAS p21 protein activator 4B [ Homo sapiens (human) ]

Gene ID: 100271927, updated on 26-Oct-2022

Summary

Official Symbol
RASA4Bprovided by HGNC
Official Full Name
RAS p21 protein activator 4Bprovided by HGNC
Primary source
HGNC:HGNC:35202
See related
Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more
Orthologs
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Genomic context

See RASA4B in Genome Data Viewer
Location:
7q22.1
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102479976..102517777, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103797581..103835325, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102120423..102158224, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene uncharacterized LOC124901715 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene uroplakin 3B like 2 Neighboring gene speedy/RINGO cell cycle regulator family member E2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ50902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras GTPase-activating protein 4B
Names
putative Ras GTPase-activating protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277335.2NP_001264264.1  ras GTPase-activating protein 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS59506.1
    UniProtKB/TrEMBL
    F5GXT2
    Related
    ENSP00000440982.1, ENST00000541662.5
    Conserved Domains (5) summary
    cd04025
    Location:134257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cl17171
    Location:542635
    PH-like; Pleckstrin homology-like domain
  2. NM_001367767.2NP_001354696.1  ras GTPase-activating protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS94160.1
    UniProtKB/Swiss-Prot
    C9J798
    Related
    ENSP00000417895.1, ENST00000465829.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102479976..102517777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419681.1XP_047275637.1  ras GTPase-activating protein 4B isoform X1

    UniProtKB/TrEMBL
    F8W6L0
    Related
    ENSP00000303968.6, ENST00000306682.6
  2. XM_047419684.1XP_047275640.1  ras GTPase-activating protein 4B isoform X4

  3. XM_047419685.1XP_047275641.1  ras GTPase-activating protein 4B isoform X4

  4. XM_047419686.1XP_047275642.1  ras GTPase-activating protein 4B isoform X5

  5. XM_047419682.1XP_047275638.1  ras GTPase-activating protein 4B isoform X2

  6. XM_047419683.1XP_047275639.1  ras GTPase-activating protein 4B isoform X3

RNA

  1. XR_007059979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103797581..103835325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)