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ERVV-2 endogenous retrovirus group V member 2, envelope [ Homo sapiens (human) ]

Gene ID: 100271846, updated on 23-Nov-2021

Summary

Official Symbol
ERVV-2provided by HGNC
Official Full Name
endogenous retrovirus group V member 2, envelopeprovided by HGNC
Primary source
HGNC:HGNC:39051
See related
Ensembl:ENSG00000268964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENVV2; HERV-V2
Summary
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages. [provided by RefSeq, Jun 2015]
Expression
Restricted expression toward placenta (RPKM 9.6) See more
Orthologs
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Genomic context

See ERVV-2 in Genome Data Viewer
Location:
19q13.41
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53044740..53051680)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53547993..53554933)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex subunit 1A pseudogene Neighboring gene endogenous retrovirus group V member 1, envelope Neighboring gene zinc finger protein 160 Neighboring gene zinc finger protein 415

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
endogenous retrovirus group V member 2 Env polyprotein
Names
HERV-V_19q13.41 provirus ancestral Env polyprotein 2
endogenous retrovirus HSV2
endogenous retrovirus group V, member 2
envelope glycoprotein ENVV2
envelope protein ENVV2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191055.2NP_001177984.1  endogenous retrovirus group V member 2 Env polyprotein precursor

    See identical proteins and their annotated locations for NP_001177984.1

    Status: REVIEWED

    Source sequence(s)
    AC010328, DA863698
    Consensus CDS
    CCDS59420.1
    UniProtKB/Swiss-Prot
    B6SEH9
    UniProtKB/TrEMBL
    M9QSX5
    Related
    ENSP00000472919.1, ENST00000601417.3
    Conserved Domains (2) summary
    cd09950
    Location:355426
    ENVV1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of the human endogenous retrovirus ENVV1, and related domains
    pfam00429
    Location:190486
    TLV_coat; ENV polyprotein (coat polyprotein)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53044740..53051680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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