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ARHGEF33 Rho guanine nucleotide exchange factor 33 [ Homo sapiens (human) ]

Gene ID: 100271715, updated on 8-Dec-2022

Summary

Official Symbol
ARHGEF33provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 33provided by HGNC
Primary source
HGNC:HGNC:37252
See related
Ensembl:ENSG00000214694 AllianceGenome:HGNC:37252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.6), brain (RPKM 0.5) and 12 other tissues See more
Orthologs
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Genomic context

See ARHGEF33 in Genome Data Viewer
Location:
2p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38889875..38975454)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38898364..38983970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39117016..39202595)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 851, pseudogene Neighboring gene MORN repeat containing 2 Neighboring gene uncharacterized LOC105374471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:39174178-39174678 Neighboring gene RNA, 7SL, cytoplasmic 96, pseudogene Neighboring gene uncharacterized LOC375196 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene RNA, U6 small nuclear 198, pseudogene Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MORN2

Homology

Clone Names

  • FLJ41381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 33
Names
DH and coiled-coil domain-containing protein ENSP00000381780
Rho guanine nucleotide exchange factor (GEF) 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145451.5NP_001138923.2  rho guanine nucleotide exchange factor 33 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC018693, AC019171
    Consensus CDS
    CCDS46263.2
    UniProtKB/Swiss-Prot
    A8MVX0
    Related
    ENSP00000387020.1, ENST00000409978.7
    Conserved Domains (1) summary
    cl02571
    Location:269445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  2. NM_001367623.3NP_001354552.1  rho guanine nucleotide exchange factor 33 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018693, AC019171
    UniProtKB/Swiss-Prot
    J3KPX2
    Conserved Domains (3) summary
    COG1196
    Location:21127
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12323
    Location:463688
    PRK12323; DNA polymerase III subunit gamma/tau
    cl02571
    Location:269436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    38889875..38975454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    38898364..38983970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)