Format

Send to:

Choose Destination

PIGK phosphatidylinositol glycan anchor biosynthesis class K [ Homo sapiens (human) ]

Gene ID: 10026, updated on 5-Dec-2021

Summary

Official Symbol
PIGKprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Kprovided by HGNC
Primary source
HGNC:HGNC:8965
See related
Ensembl:ENSG00000142892 MIM:605087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPI8; NEDHCAS
Summary
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 12.4), adrenal (RPKM 9.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PIGK in Genome Data Viewer
Location:
1p31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77088989..77219430, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (77554674..77685115, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2567 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene microRNA 7156 Neighboring gene ribosomal protein L17 pseudogene 6 Neighboring gene alanyl-tRNA synthetase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105378808 Neighboring gene Sharpr-MPRA regulatory region 3902 Neighboring gene adenylate kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphatidylinositol glycan anchor biosynthesis, class K (PIGK) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PIGK; predicted interaction to be within the endoplasmic reticulum PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GPI anchor binding TAS
Traceable Author Statement
more info
PubMed 
enables GPI-anchor transamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GPI-anchor transamidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GPI-anchor transamidase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disulfide isomerase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in attachment of GPI anchor to protein TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of GPI-anchor transamidase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 

General protein information

Preferred Names
GPI-anchor transamidase
Names
GPI transamidase subunit
GPI8 homolog
PIG-K
phosphatidylinositol glycan, class K
phosphatidylinositol-glycan biosynthesis class K protein
NP_005473.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005482.3NP_005473.1  GPI-anchor transamidase precursor

    See identical proteins and their annotated locations for NP_005473.1

    Status: REVIEWED

    Source sequence(s)
    AC093433, AC113935, AL035409
    Consensus CDS
    CCDS674.1
    UniProtKB/Swiss-Prot
    Q92643
    Related
    ENSP00000359848.3, ENST00000370812.8
    Conserved Domains (1) summary
    cl00042
    Location:42331
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    77088989..77219430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center