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MED16 mediator complex subunit 16 [ Homo sapiens (human) ]

Gene ID: 10025, updated on 25-Nov-2021

Summary

Official Symbol
MED16provided by HGNC
Official Full Name
mediator complex subunit 16provided by HGNC
Primary source
HGNC:HGNC:17556
See related
Ensembl:ENSG00000175221 MIM:604062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRIP92; THRAP5; TRAP95
Expression
Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See MED16 in Genome Data Viewer
Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (867961..893228, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (867963..893187, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene elastase, neutrophil expressed Neighboring gene complement factor D Neighboring gene RNA, U6 small nuclear 9 Neighboring gene R3H domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 9324

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 16
Names
thyroid hormone receptor-associated protein 5
thyroid hormone receptor-associated protein complex 95 kDa component
thyroid hormone receptor-associated protein, 95-kD subunit
vitamin D3 receptor-interacting protein complex 92 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005481.3NP_005472.2  mediator of RNA polymerase II transcription subunit 16

    See identical proteins and their annotated locations for NP_005472.2

    Status: VALIDATED

    Source sequence(s)
    AL137732, BC017282, BI461485, BQ015734, CB050542
    Consensus CDS
    CCDS12047.1
    UniProtKB/Swiss-Prot
    Q9Y2X0
    Related
    ENSP00000325612.1, ENST00000325464.6
    Conserved Domains (3) summary
    smart00320
    Location:70109
    WD40; WD40 repeats
    sd00039
    Location:85116
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:119828
    Med16; Mediator complex subunit 16

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    867961..893228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026121.1XP_016881610.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

  2. XM_017026120.2XP_016881609.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187622.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    47189..60469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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