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TROAP trophinin associated protein [ Homo sapiens (human) ]

Gene ID: 10024, updated on 13-Mar-2020

Summary

Official Symbol
TROAPprovided by HGNC
Official Full Name
trophinin associated proteinprovided by HGNC
Primary source
HGNC:HGNC:12327
See related
Ensembl:ENSG00000135451 MIM:603872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TASTIN
Expression
Biased expression in testis (RPKM 7.6), bone marrow (RPKM 6.1) and 11 other tissues See more
Orthologs

Genomic context

See TROAP in Genome Data Viewer
Location:
12q13.12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49323255..49331733)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49716971..49725514)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tubulin alpha 1c Neighboring gene uncharacterized LOC101927267 Neighboring gene peripherin Neighboring gene complement C1q like 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tastin
Names
trophinin assisting protein
trophinin-assisting protein (tastin)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100620.2NP_001094090.1  tastin isoform 2

    See identical proteins and their annotated locations for NP_001094090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC011597, DC410015
    Consensus CDS
    CCDS41779.1
    UniProtKB/Swiss-Prot
    Q12815
    Related
    ENSP00000369684.5, ENST00000380327.9
    Conserved Domains (1) summary
    cl25751
    Location:19132
    DUF4045; Domain of unknown function (DUF4045)
  2. NM_001278324.2NP_001265253.1  tastin isoform 3

    See identical proteins and their annotated locations for NP_001265253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC018627, CD366215, DC410015
    Consensus CDS
    CCDS61117.1
    UniProtKB/Swiss-Prot
    Q12815
    Related
    ENSP00000448313.1, ENST00000548311.5
    Conserved Domains (1) summary
    PTZ00449
    Location:19100
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
  3. NM_005480.4NP_005471.3  tastin isoform 1

    See identical proteins and their annotated locations for NP_005471.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC032583, DC410015, U04810
    Consensus CDS
    CCDS8784.1
    UniProtKB/Swiss-Prot
    Q12815
    Related
    ENSP00000257909.3, ENST00000257909.8
    Conserved Domains (3) summary
    PTZ00449
    Location:19125
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:545695
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:251364
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49323255..49331733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719181.2XP_006719244.1  tastin isoform X1

    See identical proteins and their annotated locations for XP_006719244.1

    UniProtKB/TrEMBL
    F8W130
    Related
    ENSP00000447509.1, ENST00000551245.5
    Conserved Domains (3) summary
    PTZ00449
    Location:19125
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:545695
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:251364
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
  2. XM_011537723.2XP_011536025.1  tastin isoform X2

    Conserved Domains (3) summary
    PTZ00449
    Location:19125
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:500650
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:251364
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
  3. XM_011537724.1XP_011536026.1  tastin isoform X3

    Conserved Domains (1) summary
    PHA03247
    Location:253403
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_944445.2 RNA Sequence

  2. XR_944446.2 RNA Sequence

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