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Tmem64 transmembrane protein 64 [ Mus musculus (house mouse) ]

Gene ID: 100201, updated on 26-Sep-2022

Summary

Official Symbol
Tmem64provided by MGI
Official Full Name
transmembrane protein 64provided by MGI
Primary source
MGI:MGI:2140359
See related
Ensembl:ENSMUSG00000043252 AllianceGenome:MGI:2140359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630015D15Rik
Summary
Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; and positive regulation of fat cell differentiation. Acts upstream of or within several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and regulation of ATPase activity. Located in endoplasmic reticulum. Is expressed in several structures, including brain; head mesenchyme; retina nuclear layer; thymus primordium; and vibrissa. Orthologous to human TMEM64 (transmembrane protein 64). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 76.0), genital fat pad adult (RPKM 33.2) and 26 other tissues See more
Orthologs
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Genomic context

See Tmem64 in Genome Data Viewer
Location:
4; 4 A2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15265820..15286753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15265820..15286753)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene predicted gene 11844 Neighboring gene predicted gene, 36801 Neighboring gene predicted gene, 51436 Neighboring gene predicted gene, 29883 Neighboring gene predicted gene, 29829 Neighboring gene predicted gene, 24317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 64
Names
CG11367 gene product

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181401.3NP_852066.2  transmembrane protein 64

    See identical proteins and their annotated locations for NP_852066.2

    Status: VALIDATED

    Source sequence(s)
    AK035894, AL732571, AL929532
    Consensus CDS
    CCDS17983.1
    UniProtKB/Swiss-Prot
    Q3U145, Q8K2Q6
    Related
    ENSMUSP00000055892.9, ENSMUST00000062684.9
    Conserved Domains (1) summary
    cl00429
    Location:124295
    SNARE_assoc; SNARE associated Golgi protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    15265820..15286753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)