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GM2A ganglioside GM2 activator [ Felis catus (domestic cat) ]

Gene ID: 100174922, updated on 14-May-2025
Official Symbol
GM2A
Official Full Name
ganglioside GM2 activator
Primary source
VGNC:VGNC:62603
See related
Ensembl:ENSFCTG00005025295
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Location:
chromosome: A1
Exon count:
6
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) A1 NC_058368.1 (195481259..195495804, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) A1 NC_018723.3 (198113084..198127602, complement)

Chromosome A1 - NC_058368.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 2 Neighboring gene uncharacterized LOC111562261 Neighboring gene rab9 effector protein with kelch motifs-like Neighboring gene solute carrier family 36 member 3 Neighboring gene coiled-coil domain containing 69 Neighboring gene platelet-derived growth factor receptor-like protein Neighboring gene annexin A6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis. Martin DR, et al. Acta Neuropathol, 2005 Nov. PMID 16200419
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ganglioside GM2 activator
Names
GM2 activator protein
GM2 ganglioside activator

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058368.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    195481259..195495804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045036675.1 → XP_044892610.1  ganglioside GM2 activator isoform X2

    UniProtKB/TrEMBL
    Q6Q7X5
    Conserved Domains (1) summary
    cl00274
    Location:4 → 164
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

  2. XM_003981379.6 → XP_003981428.3  ganglioside GM2 activator isoform X1

    Related
    ENSFCTP00005050932.1, ENSFCTT00005071823.1
    Conserved Domains (1) summary
    cl00274
    Location:32 → 192
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

  3. XM_045036676.1 → XP_044892611.1  ganglioside GM2 activator isoform X3

    UniProtKB/TrEMBL
    Q6Q7X5
    Conserved Domains (1) summary
    cl00274
    Location:3 → 163
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
Nucleotide Protein
Heading Accession and Version

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