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DGKA diacylglycerol kinase alpha [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100172456, updated on 3-Apr-2024

Summary

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Gene symbol
DGKA
Gene description
diacylglycerol kinase alpha
Locus tag
CR201_G0027849
See related
Ensembl:ENSPPYG00000004636
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 10 NC_071995.2 (53825253..53848666)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 12 NC_071997.1 (53826123..53849536)

Chromosome 10 - NC_071995.2Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase P-like Neighboring gene U6 spliceosomal RNA Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene U2 spliceosomal RNA Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • DKFZp468L126

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase alpha
Names
diacylglycerol kinase, alpha 80kDa
NP_001125544.1
XP_009246138.1
XP_009246139.1
XP_009246141.1
XP_054382332.1
XP_063567623.1
XP_063567624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001132072.2 → NP_001125544.1  diacylglycerol kinase alpha

    See identical proteins and their annotated locations for NP_001125544.1

    Status: PROVISIONAL

    Source sequence(s)
    CR858739
    UniProtKB/TrEMBL
    A0A2J8UI10, H2NHM6, Q5RBB2
    Related
    ENSPPYP00000027657.1, ENSPPYT00000041852.1
    Conserved Domains (5) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071995.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    53825253..53848666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009247863.2 → XP_009246138.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_009246138.1

    UniProtKB/TrEMBL
    A0A2J8UI10, H2NHM6, Q5RBB2
    Related
    ENSPPYP00000005281.3
    Conserved Domains (5) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_009247864.4 → XP_009246139.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_009246139.1

    UniProtKB/TrEMBL
    A0A2J8UI10, H2NHM6, Q5RBB2
    Conserved Domains (5) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_063711553.1 → XP_063567623.1  diacylglycerol kinase alpha isoform X2

    UniProtKB/TrEMBL
    A0A2J8UI10, H2NHM6

  4. XM_054526357.1 → XP_054382332.1  diacylglycerol kinase alpha isoform X1

    UniProtKB/TrEMBL
    A0A8I5YK40

  5. XM_009247866.3 → XP_009246141.1  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    Q5RBB2
    Conserved Domains (5) summary
    smart00045
    Location:408 → 589
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:266 → 387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:266 → 599
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    pfam00130
    Location:94 → 142
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl08302
    Location:30 → 71
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_063711554.1 → XP_063567624.1  diacylglycerol kinase alpha isoform X4

Nucleotide Protein
Heading Accession and Version

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