U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

chata choline O-acetyltransferase a [ Danio rerio (zebrafish) ]

Gene ID: 100170938, updated on 24-Dec-2022

Summary

Official Symbol
chataprovided by ZNC
Official Full Name
choline O-acetyltransferase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080102-2
See related
Ensembl:ENSDARG00000015854 AllianceGenome:ZFIN:ZDB-GENE-080102-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chat; unm_tk64
Summary
Predicted to enable choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to be active in cytoplasm and neuron projection. Is expressed in brain; neurons; post-vent region; and spinal cord. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See chata in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (29407978..29421723, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (29278654..29291069, complement)
103 previous assembly Zv9 (GCF_000002035.4) 13 NC_007124.5 (29631584..29645406, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase a Neighboring gene oxoglutarate dehydrogenase L Neighboring gene zgc:153142 Neighboring gene solute carrier family 18 member 3a Neighboring gene retinal G protein coupled receptor a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables choline O-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables choline O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
choline O-acetyltransferase
Names
CHOACTase
baj
choline acetylase
choline acetyltransferase
unm tk64
NP_001124191.1
XP_005156786.1
XP_021336163.1
XP_021336164.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130719.1NP_001124191.1  choline O-acetyltransferase

    See identical proteins and their annotated locations for NP_001124191.1

    Status: PROVISIONAL

    Source sequence(s)
    EU660883
    UniProtKB/Swiss-Prot
    B2ZGJ1
    UniProtKB/TrEMBL
    A0A8M9Q9G1
    Related
    ENSDARP00000025508.7, ENSDART00000024225.7
    Conserved Domains (1) summary
    pfam00755
    Location:18601
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    29407978..29421723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480488.1XP_021336163.1  choline O-acetyltransferase isoform X1

    UniProtKB/Swiss-Prot
    B2ZGJ1
    UniProtKB/TrEMBL
    A0A8M9Q9G1
    Conserved Domains (1) summary
    pfam00755
    Location:18601
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  2. XM_005156729.4XP_005156786.1  choline O-acetyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005156786.1

    UniProtKB/Swiss-Prot
    B2ZGJ1
    UniProtKB/TrEMBL
    A0A8M9Q9G1
    Related
    ENSDARP00000125038.1, ENSDART00000150228.3
    Conserved Domains (1) summary
    pfam00755
    Location:18601
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  3. XM_021480489.1XP_021336164.1  choline O-acetyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8M9QF55
    Conserved Domains (1) summary
    pfam00755
    Location:18391
    Carn_acyltransf; Choline/Carnitine o-acyltransferase