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ulk1a unc-51 like autophagy activating kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 100170793, updated on 17-Aug-2026
Official Symbol
ulk1aprovided by ZNC
Official Full Name
unc-51 like autophagy activating kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080723-31
See related
Ensembl:ENSDARG00000062518 AllianceGenome:ZFIN:ZDB-GENE-080723-31
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:195008
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation and regulation of autophagy. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See ulk1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (52160822..52200557, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (43736072..43775805, complement)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496381 Neighboring gene E1A binding protein p400 Neighboring gene small nucleolar RNA SNORA49 Neighboring gene uncharacterized LOC141375551 Neighboring gene uncharacterized LOC141375552

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Vps34 knockdown attenuated AlNPs-induced neurodevelopmental toxicity in zebrafish larvae and adults by inhibiting mitophagy. Zhang Y, et al. Aquat Toxicol, 2025 Sep. PMID 40616935
  2. Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. He C, et al. Autophagy, 2009 May. PMID 19221467, Free PMC Article
  3. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Yatsuka H, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333712
  4. Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish. Zhu P, et al. JCI Insight, 2024 Apr 8. PMID 38412038, Free PMC Article
  5. Low-dose methylmercury exposure impairs the locomotor activity of zebrafish: Role of intestinal inositol metabolism. Zhu J, et al. Environ Res, 2020 Nov. PMID 32777273

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine-protein kinase ULK1a
Names
unc-51-like kinase 1a
NP_001124103.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130631.1 → NP_001124103.1  serine/threonine-protein kinase ULK1a

    See identical proteins and their annotated locations for NP_001124103.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163488
    UniProtKB/TrEMBL
    A0A8M1NIT9, B3DJH7
    Related
    ENSDARP00160018616.1, ENSDART00160033293.1
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:6 → 272
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:713 → 924
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    52160822..52200557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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