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Phactr4 phosphatase and actin regulator 4 [ Mus musculus (house mouse) ]

Gene ID: 100169, updated on 26-Sep-2022

Summary

Official Symbol
Phactr4provided by MGI
Official Full Name
phosphatase and actin regulator 4provided by MGI
Primary source
MGI:MGI:2140327
See related
Ensembl:ENSMUSG00000066043 AllianceGenome:MGI:2140327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4120; 3110001B12Rik; C330013F19Rik
Summary
Enables actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Located in lamellipodium. Is expressed in central nervous system and retina. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.0), limb E14.5 (RPKM 5.9) and 28 other tissues See more
Orthologs
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Genomic context

See Phactr4 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132083233..132149759, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132355922..132422446, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element for Atpif1, Phactr4, Ptpru, Rcc1 and Snhg3 Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene small nucleolar RNA host gene 3 Neighboring gene predicted gene, 23055 Neighboring gene mediator complex subunit 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13171, KIAA4120

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphatase and actin regulator 4
Names
humdy
protein Humpty dumpty

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161797.1NP_001155269.1  phosphatase and actin regulator 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AK029356, BB849287, BC075672, BY294063, CN460852
    Consensus CDS
    CCDS51318.1
    UniProtKB/Swiss-Prot
    Q501J7
    Related
    ENSMUSP00000081185.6, ENSMUST00000084170.12
    Conserved Domains (1) summary
    smart00707
    Location:549573
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
  2. NM_175306.4NP_780515.2  phosphatase and actin regulator 4 isoform 1

    See identical proteins and their annotated locations for NP_780515.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029356, BB849287, BC075672, BY294063
    Consensus CDS
    CCDS18724.1
    UniProtKB/Swiss-Prot
    Q501J7, Q8C7U9
    Related
    ENSMUSP00000099628.4, ENSMUST00000102568.10
    Conserved Domains (2) summary
    smart00707
    Location:576600
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:6486
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132083233..132149759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163538.1XP_036019431.1  phosphatase and actin regulator 4 isoform X3

    Conserved Domains (1) summary
    smart00707
    Location:491515
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
  2. XM_006538456.5XP_006538519.1  phosphatase and actin regulator 4 isoform X1

    UniProtKB/Swiss-Prot
    Q501J7
    Related
    ENSMUSP00000081270.5, ENSMUST00000084249.11
    Conserved Domains (2) summary
    smart00707
    Location:586610
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:7597
    RPEL; RPEL repeat
  3. XM_006538457.5XP_006538520.1  phosphatase and actin regulator 4 isoform X2

    Conserved Domains (1) summary
    smart00707
    Location:559583
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
  4. XM_011250172.2XP_011248474.1  phosphatase and actin regulator 4 isoform X5

    Conserved Domains (1) summary
    smart00707
    Location:302326
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
  5. XM_036163539.1XP_036019432.1  phosphatase and actin regulator 4 isoform X4

    Conserved Domains (1) summary
    pfam02755
    Location:7597
    RPEL; RPEL repeat