U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

usp15 ubiquitin specific peptidase 15 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100158604, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
usp15provided by Xenbase
Official Full Name
ubiquitin specific peptidase 15provided by Xenbase
Primary source
Xenbase:XB-GENE-1008519
See related
Ensembl:ENSXETG00000021472
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (62714656..62762087, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (53229485..53276733, complement)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene protein phosphatase 1 regulatory subunit 12A Neighboring gene TAFA chemokine like family member 2 Neighboring gene solute carrier family 16 member 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling. Herhaus L, et al. Open Biol, 2014 May. PMID 24850914, Free PMC Article
  2. The genome of the Western clawed frog Xenopus tropicalis. Hellsten U, et al. Science, 2010 Apr 30. PMID 20431018, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 by interacting with and deubiquitylating ALK3.
    Title: USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within monoubiquitinated protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription elongation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 15
Names
Deubiquitinating enzyme 15
Ubiquitin thioesterase 15
Ubiquitin-specific-processing protease 15
NP_001121498.1
XP_012814096.1
XP_012814097.1
XP_012814098.1
XP_031753530.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128026.1 → NP_001121498.1  ubiquitin carboxyl-terminal hydrolase 15

    See identical proteins and their annotated locations for NP_001121498.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166318
    UniProtKB/TrEMBL
    A0A6I8T238
    Related
    ENSXETP00000082673.2, ENSXETT00000093923.2
    Conserved Domains (6) summary
    smart00695
    Location:23 → 121
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:27 → 903
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:755 → 902
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:260 → 444
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:461 → 567
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:135 → 222
    Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    62714656..62762087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012958642.3 → XP_012814096.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

    UniProtKB/TrEMBL
    A0A6I8T238, A0A8J0SHV6
    Conserved Domains (1) summary
    COG5560
    Location:27 → 932
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  2. XM_012958643.3 → XP_012814097.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

    See identical proteins and their annotated locations for XP_012814097.1

    UniProtKB/Swiss-Prot
    B2GUK6, F6Z5C0, F6ZNA0
    UniProtKB/TrEMBL
    A0A6I8RPZ4
    Related
    ENSXETP00000061641.2, ENSXETT00000066127.3
    Conserved Domains (1) summary
    COG5560
    Location:27 → 932
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  3. XM_012958644.3 → XP_012814098.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X3

    UniProtKB/TrEMBL
    A0A6I8RPZ4
    Related
    ENSXETP00000100741.2, ENSXETT00000077006.2
    Conserved Domains (1) summary
    COG5560
    Location:27 → 903
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  4. XM_031897670.1 → XP_031753530.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X4

    UniProtKB/TrEMBL
    A0A8J1J938
    Conserved Domains (1) summary
    COG5560
    Location:27 → 620
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F6Z5C0.2 GenPept UniProtKB/Swiss-Prot:F6Z5C0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.