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TSC1 TSC complex subunit 1 [ Sus scrofa (pig) ]

Gene ID: 100154726, updated on 5-Sep-2025
Official Symbol
TSC1provided by VGNC
Official Full Name
TSC complex subunit 1provided by VGNC
Primary source
VGNC:VGNC:109544
See related
Ensembl:ENSSSCG00000046003 RGD:13896358
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in ovary (RPKM 15.7), kidney (RPKM 12.2) and 8 other tissues See more
Orthologs
all
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See TSC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (272636530..272685948, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (306795196..306819962, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene sperm acrosome associated 9 Neighboring gene uncharacterized LOC110256471 Neighboring gene growth factor independent 1B transcriptional repressor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. MiR-126-3p promotes the cell proliferation and inhibits the cell apoptosis by targeting TSC1 in the porcine granulosa cells. Yuan X, et al. In Vitro Cell Dev Biol Anim, 2018 Dec. PMID 30341633
  2. A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex. Li X, et al. J Genet Genomics, 2020 Dec 20. PMID 33612456
  3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex.
    Title: A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex.
  2. These findings would provide of great insight in further exploring the molecular regulation of miR-126-3p and TSC1 on the functions of granulosa cells during the folliculogenesis in mammals.
    Title: MiR-126-3p promotes the cell proliferation and inhibits the cell apoptosis by targeting TSC1 in the porcine granulosa cells.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of TSC1-TSC2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hamartin
Names
tuberous sclerosis 1
XP_020926473.1

Length

  • 1167

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    272636530..272685948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021070814.1 → XP_020926473.1  hamartin

    UniProtKB/TrEMBL
    A0A0B8RT18
    Related
    ENSSSCP00000072801.1, ENSSSCT00000086196.1
    Conserved Domains (2) summary
    pfam04388
    Location:8 → 718
    Hamartin; Hamartin protein
    cl25732
    Location:704 → 970
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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