cdkn1a cyclin dependent kinase inhibitor 1A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdkn1aprovided by ZNC
Official Full Name: cyclin dependent kinase inhibitor 1Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-7
See related: Ensembl:ENSDARG00000076554 AllianceGenome:ZFIN:ZDB-GENE-070705-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p21; cip1; waf1; si:ch1073-48m5.2
Summary: Predicted to enable protein kinase inhibitor activity. Acts upstream of or within aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	22	NC_133197.1 (620515..625947, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (602385..607817, complement)

Chromosome 22 - NC_133197.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels.
Title: Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels.
Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression.
Title: Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression.
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
Title: New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aorta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128420.1 → NP_001121892.1 cyclin-dependent kinase inhibitor 1

See identical proteins and their annotated locations for NP_001121892.1

Status: VALIDATED

Source sequence(s)

JBMGRA010000022, KC818434

UniProtKB/TrEMBL

A5WWG2, M9TFN8

Related

ENSDARP00000114199.1, ENSDART00000145983.2

Conserved Domains (1) summary

pfam02234
Location:19 → 60

CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133197.1 Reference GRCz12tu Primary Assembly

Range

620515..625947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003200914.6 → XP_003200962.1 cyclin-dependent kinase inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8M1RFS1

Related

ENSDARP00000117888.1, ENSDART00000136722.2

Conserved Domains (1) summary

pfam02234
Location:35 → 76

CDI; Cyclin-dependent kinase inhibitor