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prkcdb protein kinase C, delta b [ Danio rerio (zebrafish) ]

Gene ID: 100150844, updated on 11-Apr-2024

Summary

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Official Symbol
prkcdbprovided by ZNC
Official Full Name
protein kinase C, delta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-111129-1
See related
Ensembl:ENSDARG00000070651 AllianceGenome:ZFIN:ZDB-GENE-111129-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkcd
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within apoptotic process and protein phosphorylation. Predicted to be located in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and hypertension. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18347519..18384554, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18185155..18222207, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911829 Neighboring gene uncharacterized LOC103911830 Neighboring gene FYVE, RhoGEF and PH domain containing 5a Neighboring gene death inducer-obliterator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. GAK and PRKCD are positive regulators of PRKN-independent mitophagy. Munson MJ, et al. Nat Commun, 2021 Oct 20. PMID 34671015, Free PMC Article
  2. Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Yang F, et al. Chemosphere, 2018 Dec. PMID 30265984
  3. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
  4. Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Lisse TS, et al. Sci Rep, 2016 Feb 5. PMID 26846883, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kinase C delta type; protein kinase C, delta b
XP_001919906.4
XP_021335469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365237.1 → NP_001352166.1  protein kinase C, delta b

    Status: VALIDATED

    Source sequence(s)
    BX005175
    UniProtKB/TrEMBL
    A0A8M9QDJ7, E7F4L5
    Conserved Domains (2) summary
    pfam00130
    Location:232 → 284
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:362 → 677
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    18347519..18384554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479794.1 → XP_021335469.1  protein kinase C delta type

    UniProtKB/TrEMBL
    A0A8M9QDJ7, E7F4L5
    Related
    ENSDARP00000129177.1, ENSDART00000156499.2
    Conserved Domains (2) summary
    pfam00130
    Location:232 → 284
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:362 → 677
    PKc_like; Protein Kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394814.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    262700..299735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919871.7 → XP_001919906.4  protein kinase C delta type

    UniProtKB/TrEMBL
    A0A8M9QDJ7, E7F4L5
    Conserved Domains (2) summary
    pfam00130
    Location:232 → 284
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:362 → 677
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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